6-(Hydroxymethyl)-8-oxo-4,8-dihydropyrano[3,2-b]pyrans as New Tyrosinase Inhibitors and Antioxidant Agents,ChemistrySelect

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6-(Hydroxymethyl)-8-oxo-4,8-dihydropyrano[3,2-b]pyrans as New Tyrosinase Inhibitors and Antioxidant Agents
ChemistrySelect ( IF 1.9 ) Pub Date : 2023-11-15 , DOI: 10.1002/slct.202302990
Sara Ranjbar _{1,

2} , Sara Razmara ₃ , Sara Khademian ₃ , Zeinab Malekzadeh _{1,

2} , Maryam Kabiri ₃ , Younes Ghasemi _{1,

4} , Mehdi Khoshneviszadeh _{2,

5}

Affiliation

A series of substituted 6-(Hydroxymethyl)-8-oxo-4,8-dihydropyrano[3,2-b]pyran derivatives were synthesized. All compounds were screened for their tyrosinase inhibtory and free radical scavenging activities. Compound 1 was the most potent tyrosinase inhibitor (IC₅₀=52.1 μM). Compound 2 was discovered as a tyrosinase inhibitor (IC₅₀=80.7 μM) having remarkable free radical scavenging activity (EC₅₀=15.3 μM).

中文翻译：

6-(羟甲基)-8-氧代-4,8-二氢吡喃并[3,2-b]吡喃作为新型酪氨酸酶抑制剂和抗氧化剂

合成了一系列取代的6-(羟甲基)-8-氧代-4,8-二氢吡喃并[3,2- b ]吡喃衍生物。对所有化合物的酪氨酸酶抑制和自由基清除活性进行了筛选。化合物1是最有效的酪氨酸酶抑制剂(IC ₅₀ =52.1 μM)。化合物2被发现是一种酪氨酸酶抑制剂(IC ₅₀ =80.7 μM)，具有显着的自由基清除活性(EC ₅₀ =15.3 μM)。

更新日期：2023-11-16

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