For sustained and stable improvement of the diabetic wound microenvironment, a temperature-sensitive composite hydrogel (ZnDBs/HBC) composed of inorganic zinc mineralized diatom biosilica (ZnDBs) and hydroxybutyl chitosan (HBC) was developed. The interfacial anchoring effect between ZnDBs and HBC enhanced the mechanical strength of the hydrogel. The mechanical strength of the composite hydrogel containing 3 wt% ZnDBs was increased by nearly 2.3times. The hydrogel can be used as a carrier for sustained release of Zn²⁺ for at least 72 h. In diabetic rats models, ZnDBs/HBC composite hydrogel could accelerate the inflammatory process by regulating the expression of pro-inflammatory factor IL-6 and anti-inflammatory factor IL-10, and also promote tissue cell proliferation and collagen deposition, thereby restoring the normal healing process and accelerating wound healing. The wound contraction rate of the composite hydrogel group was more than 2 times that of the control group. Therefore, ZnDBs/HBC composite hydrogel has the potential to be used as a therapeutic dressing for diabetic chronic wounds.

为了持续稳定地改善糖尿病伤口微环境，开发了由无机锌矿化硅藻生物二氧化硅（ZnDBs）和羟丁基壳聚糖（HBC）组成的温敏复合水凝胶（ZnDBs/HBC）。 ZnDBs和HBC之间的界面锚定效应增强了水凝胶的机械强度。含有3 wt% ZnDBs的复合水凝胶的机械强度提高了近2.3倍。该水凝胶可用作持续释放Zn ²⁺至少72小时的载体。在糖尿病大鼠模型中，ZnDBs/HBC复合水凝胶可通过调节促炎因子IL-6和抗炎因子IL-10的表达，加速炎症过程，并促进组织细胞增殖和胶原沉积，从而恢复正常的炎症反应。愈合过程并加速伤口愈合。复合水凝胶组的伤口收缩率是对照组的2倍以上。因此，ZnDBs/HBC复合水凝胶有潜力用作糖尿病慢性伤口的治疗敷料。