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Dearomative Insertion of Fluoroalkyl Carbenes into Azoles Leading to Fluoroalkyl Heterocycles with a Quaternary Center
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2023-11-15 , DOI: 10.1002/anie.202313807
Linxuan Li 1 , Yongquan Ning 1 , Hongzhu Chen 1 , Yongyue Ning 1 , Paramasivam Sivaguru 1 , Peiqiu Liao 1 , Qingwen Zhu 1 , Yong Ji 1 , Graham de Ruiter 2 , Xihe Bi 1, 3
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2023-11-15 , DOI: 10.1002/anie.202313807
Linxuan Li 1 , Yongquan Ning 1 , Hongzhu Chen 1 , Yongyue Ning 1 , Paramasivam Sivaguru 1 , Peiqiu Liao 1 , Qingwen Zhu 1 , Yong Ji 1 , Graham de Ruiter 2 , Xihe Bi 1, 3
Affiliation
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A general skeletal ring expansion strategy was developed for the direct conversion of azoles into various heterocyclic frameworks containing fluoroalkyl-substituted quaternary centers through dearomative one-carbon insertion using fluoroalkyl N-triftosylhydrazones. The method is scalable, tolerates diverse functional groups, and is amenable to the synthesis of medicinally relevant molecules.
中文翻译:
氟烷基卡宾脱芳香插入唑类中形成具有四元中心的氟烷基杂环
开发了一种通用的骨架环扩展策略,用于通过使用氟烷基N-三甲苯基腙进行脱芳香一碳插入,将唑类直接转化为各种含有氟烷基取代的季中心的杂环骨架。该方法具有可扩展性,可耐受不同的官能团,并且适合医学相关分子的合成。
更新日期:2023-11-15
中文翻译:
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氟烷基卡宾脱芳香插入唑类中形成具有四元中心的氟烷基杂环
开发了一种通用的骨架环扩展策略,用于通过使用氟烷基N-三甲苯基腙进行脱芳香一碳插入,将唑类直接转化为各种含有氟烷基取代的季中心的杂环骨架。该方法具有可扩展性,可耐受不同的官能团,并且适合医学相关分子的合成。