INTRODUCTION High rates of disease- and treatment-related symptoms, such as bone lesions, in people with multiple myeloma (MM) create uncertainty on the safety and feasibility of exercise. This study determined the safety, feasibility, and acceptability of an individualized exercise medicine program for people with MM at any disease stage. METHODS A multisite, randomized waitlist-controlled trial was conducted of an individualized, high-intensity aerobic, resistance, and impact-loading exercise program. The exercise sessions were supervised twice weekly by accredited exercise physiologists, with one additional unsupervised session per week, for 12 wk. Safety was determined by number of adverse and serious adverse events. Feasibility outcome measures were study eligibility, recruitment, adherence, and attrition. Acceptability was determined by qualitative interviews and subjective levels of enjoyment. RESULTS Of 203 people with MM screened, 88% were eligible, with 34% accepting participation (60 people) and 20% attrition for the between-group analysis, meeting a priori criteria (≥25% and <25%, respectively). No adverse or serious adverse events attributed to testing and/or exercise training were reported. Attendance at supervised exercise sessions was 98%, with 45% completion of the home-based exercise sessions. Adherence rates were 35%, 63%, and 34% for the aerobic, resistance, and impact-loading protocols, with 55%, 80%, and 37% of participants meeting a priori criteria (75% of protocol). Acceptability of the exercise program was high (mean, 82%; 95% confidence interval, 78%-87%) and highly supported by qualitative responses. CONCLUSIONS An individualized, high-intensity aerobic, resistance, and impact-loading exercise medicine program is safe and acceptable, and feasible by some measures for people with MM. Adherence to the prescribed exercise protocols was limited by comorbidities and disease symptoms. Strategies to improve unsupervised exercise completion are warranted in this population.

中文翻译：

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针对多发性骨髓瘤患者的多部位个体化运动干预的安全性、可行性和可接受性。

简介 多发性骨髓瘤 (MM) 患者出现骨病变等疾病和治疗相关症状的比例很高，这给运动的安全性和可行性带来了不确定性。这项研究确定了针对任何疾病阶段的多发性骨髓瘤患者的个体化运动医学计划的安全性、可行性和可接受性。方法 对个体化、高强度有氧运动、阻力运动和冲击负荷运动计划进行多中心、随机等待对照试验。经认可的运动生理学家每周对运动课程进行两次监督，每周额外进行一次无人监督的运动，持续 12 周。安全性由不良事件和严重不良事件的数量决定。可行性结果衡量指标包括研究资格、招募、依从性和流失。可接受性由定性访谈和主观享受程度决定。结果 在接受筛查的 203 名 MM 患者中，88% 符合资格，其中 34% 接受参与（60 人），20% 退出组间分析，满足先验标准（分别≥25% 和 <25%）。没有报告因测试和/或运动训练引起的不良或严重不良事件。监督锻炼课程的参加率为 98%，其中 45% 完成了家庭锻炼课程。有氧运动、阻力运动和冲击负荷方案的遵守率分别为 35%、63% 和 34%，其中 55%、80% 和 37% 的参与者满足先验标准（方案的 75%）。锻炼计划的可接受性很高（平均值为 82%；95% 置信区间为 78%-87%），并且得到了定性反应的高度支持。结论 对于 MM 患者来说，个体化、高强度有氧、抗阻和冲击负荷运动医学计划是安全且可接受的，并且通过某些措施是可行的。遵守规定的锻炼方案受到合并症和疾病症状的限制。对于这一人群，有必要采取提高无人监督运动完成率的策略。