Functional Covalent Organic Framework (COF) Nanoparticles for Biomimic Mineralization and Bacteria Inhabitation,ACS Applied Materials & Interfaces

当前位置： X-MOL 学术 › ACS Appl. Mater. Interfaces › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Functional Covalent Organic Framework (COF) Nanoparticles for Biomimic Mineralization and Bacteria Inhabitation
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2023-11-02 , DOI: 10.1021/acsami.3c13249
Tian Zhang ₁ , Lingli Wu ₂ , Yaru Song ₁ , Xiaojuan Li ₁ , Xinxin Niu ₁ , Yajing Sun ₁ , Jie Liu ₃ , Guangyuan Feng ₁ , Shengbin Lei _{1,

4}

Affiliation

Biomimic mineralization of hard tissues with hierarchical structures is a challenging task, while designing multifunctional materials possessing both the ability of biomimic mineralization and drug delivery is even more difficult. Herein, inspired by the multilevel structure and mineralization ability of amelogenin, a novel carboxyl-functionalized covalent organic framework (COF) nanosphere material was designed and synthesized, which exhibited a significant biomimetic remineralization ability as demonstrated on SiO₂ glass, Ti₆Al₄V, and an acid-etched enamel surface. Furthermore, the nanoporous structure also enables the COF nanospheres to serve as a drug delivery system for the controlled release of antibacterial drugs. This work provides a promising strategy for the design of multifunctional biomimic materials.

中文翻译：

用于仿生矿化和细菌抑制的功能性共价有机框架（COF）纳米颗粒

具有分级结构的硬组织的仿生矿化是一项具有挑战性的任务，而设计兼具仿生矿化和药物输送能力的多功能材料则更加困难。在此，受牙釉蛋白多级结构和矿化能力的启发，设计并合成了一种新型羧基功能化共价有机骨架（COF）纳米球材料，该材料在SiO 2 玻璃、Ti 6 Al 4 V 上表现出显着_的仿生_再矿化_能力。和酸蚀搪瓷表面。此外，纳米多孔结构还使COF纳米球能够作为抗菌药物控释的药物递送系统。这项工作为多功能仿生材料的设计提供了一种有前景的策略。

更新日期：2023-11-02

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南