Abstract

Nitrogen-containing organofluorine derivatives, which are prepared using fluorinated building blocks, are among the most important active fragments in various pharmaceutical and agrochemical products. This review focuses on the reactivity, synthesis, and applications of fluoromethylated hydrazones and acylhydrazones. It summarizes recent methodologies that have been used for the synthesis of various nitrogen-containing organofluorine compounds.

Beilstein J. Org. Chem. 2023, 19, 1741–1754. doi:10.3762/bjoc.19.127

中文翻译：

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三氟甲基化腙和酰腙作为有效的含氮氟化结构单元

摘要

使用氟化结构单元制备的含氮有机氟衍生物是各种医药和农化产品中最重要的活性片段之一。本综述重点关注氟甲基化腙和酰腙的反应性、合成和应用。它总结了用于合成各种含氮有机氟化合物的最新方法。

贝尔斯坦 J. 组织。化学。 2023, 19, 1741–1754。doi:10.3762/bjoc.19.127