<br>m6A修饰与lncRNA在癌症耐药性中相互作用的新见解,Cell Proliferation

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m6A修饰与lncRNA在癌症耐药性中相互作用的新见解
Cell Proliferation ( IF 5.9 ) Pub Date : 2023-11-14 , DOI: 10.1111/cpr.13578
Yizhou Jin ₁ , Zhipeng Fan _{1,

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Affiliation

耐药性可能是改善癌症患者预后的最大障碍，导致各种癌症的复发、进展和转移。探索其潜在机制值得进一步研究。 N6-甲基腺苷（m6A）是真核生物中最常见的RNA修饰，在RNA翻译、运输、稳定性、降解、剪接和加工中发挥着至关重要的作用。长非编码RNA (lncRNA) 是指一组长度超过200 个核苷酸(nt) 且通常缺乏编码蛋白质的能力的转录本。 LncRNA已被确定在调节肿瘤发生和进展的多个方面发挥重要作用，包括增殖、转移、代谢和治疗耐药。近年来，越来越多的证据出现，强调了 m6A 修饰和 lncRNA 之间的相互作用在确定癌细胞对化疗药物敏感性方面的关键作用。在这篇综述中，我们重点关注 m6A 修饰与 lncRNA 之间相互作用在调节癌症耐药性方面的最新进展。此外，我们的目标是探索这个过程中涉及的潜在机制。本综述的目的是提供有价值的见解，并为逆转癌症化疗耐药性的未来潜在方向提出建议。

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New insights into the interaction between m6A modification and lncRNA in cancer drug resistance

Drug resistance is perhaps the greatest obstacle in improving outcomes for cancer patients, leading to recurrence, progression and metastasis of various cancers. Exploring the underlying mechanism worth further study. N6-methyladenosine (m6A) is the most common RNA modification found in eukaryotes, playing a vital role in RNA translation, transportation, stability, degradation, splicing and processing. Long noncoding RNA (lncRNA) refers to a group of transcripts that are longer than 200 nucleotides (nt) and typically lack the ability to code for proteins. LncRNA has been identified to play a significant role in regulating multiple aspects of tumour development and progression, including proliferation, metastasis, metabolism, and resistance to treatment. In recent years, a growing body of evidence has emerged, highlighting the crucial role of the interplay between m6A modification and lncRNA in determining the sensitivity of cancer cells to chemotherapeutic agents. In this review, we focus on the recent advancements in the interaction between m6A modification and lncRNA in the modulation of cancer drug resistance. Additionally, we aim to explore the underlying mechanisms involved in this process. The objective of this review is to provide valuable insights and suggest potential future directions for the reversal of chemoresistance in cancer.

更新日期：2023-11-14

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