Toxicities of Legacy and Current-Use PFAS in an Anuran: Do Larval Exposures Influence Responses to a Terrestrial Pathogen Challenge?,Environmental Science & Technology

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Toxicities of Legacy and Current-Use PFAS in an Anuran: Do Larval Exposures Influence Responses to a Terrestrial Pathogen Challenge?
Environmental Science & Technology ( IF 10.8 ) Pub Date : 2023-11-14 , DOI: 10.1021/acs.est.3c03191
Evelyn M Barragan ₁ , Tyler D Hoskins ₁ , Elizabeth B Allmon ₁ , Jessica L McQuigg ₂ , Matthew T Hamilton ₁ , Erin N Christian ₁ , Grace S M Coogan ₁ , Catherine L Searle ₃ , Youn Jeong Choi ₄ , Linda S Lee ₄ , Jason T Hoverman ₁ , Maria S Sepúlveda _{1,

5}

Affiliation

Legacy polyfluoroalkyl substances (PFAS) [perfluorooctanesulfonate (PFOS) and perfluorooctanoic acid (PFOA)] are being replaced by various other fluorinated compounds, such as hexafluoropropylene oxide dimer acid (GenX). These alternatives are thought to be less bioaccumulative and, therefore, less toxic than legacy PFAS. Contaminant exposures occur concurrently with exposure to natural stressors, including the fungal pathogen Batrachocytrium dendrobatidis (Bd). Despite evidence that other pollutants can increase the adverse effects of Bd on anurans, no studies have examined the interactive effects of Bd and PFAS. This study tested the growth and developmental effects of PFOS, PFOA, and GenX on gray treefrog (Hyla versicolor) tadpoles, followed by a Bd challenge after metamorphosis. Despite PFAS exposure only occurring during the larval stage, carry-over effects on growth were observed post metamorphosis. Further, PFAS interacted with Bd exposure to influence growth; Bd-exposed animals had significantly shorter SVL [snout–vent length (mm)] with significantly increased body condition, among other time-dependent effects. Our data suggest that larval exposure to PFAS can continue to impact growth in the juvenile stage after exposure has ended. Contrary to predictions, GenX affected terrestrial performance more consistently than its legacy congener, PFOA. Given the role of Bd in amphibian declines, further investigation of interactions of PFAS with Bd and other environmentally relevant pathogens is warranted.

中文翻译：

无尾猿中传统和当前使用的 PFAS 的毒性：幼虫暴露会影响对陆地病原体挑战的反应吗？

传统的多氟烷基物质 (PFAS) [全氟辛烷磺酸盐 (PFOS) 和全氟辛酸 (PFOA)] 正在被各种其他氟化化合物所取代，例如六氟环氧丙烷二聚酸 (GenX)。这些替代品被认为生物累积性较低，因此比传统的 PFAS 毒性更小。污染物暴露与自然应激源同时发生，包括真菌病原体Batrachocytrium dendrobatidis ( Bd )。尽管有证据表明其他污染物会增加Bd对无尾动物的不利影响，但没有研究检验Bd和 PFAS 的相互作用。本研究测试了 PFOS、PFOA 和 GenX 对灰树蛙 ( Hyla versicolor ) 蝌蚪的生长和发育影响，以及变态后的Bd攻击。尽管 PFAS 暴露仅发生在幼虫阶段，但在变态后观察到对生长的残留影响。此外，PFAS 与Bd暴露相互作用，影响生长；除其他时间依赖性效应外， Bd暴露动物的 SVL [鼻孔长度 (mm)] 显着缩短，身体状况显着改善。我们的数据表明，接触 PFAS 的幼虫在接触结束后会继续影响幼虫阶段的生长。与预测相反，GenX 对地面性能的影响比其传统同系物 PFOA 更一致。鉴于Bd在两栖动物数量减少中的作用，有必要进一步研究 PFAS 与Bd和其他环境相关病原体的相互作用。

更新日期：2023-11-14

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