PHF5A is a member of the zinc-finger proteins. To advance knowledge on their role in carcinogenesis, data from experimental studies, animal models and clinical studies in different tumorigenesis have been reviewed. Furthermore, PHF5A as an oncogenic function, is frequently high expressed in tumor cells and a potential prognostic marker for different cancers. PHF5A is implicated in the regulation of cancer cell proliferation, invasion, migration and metastasis. Knockdown of PHF5A prevented the invasion and metastasis of tumor cells. Here, the role of PHF5A in different cancers and their possible mechanism in relation to recent literature is reviewed and discussed. There is an open promising perspective to their therapeutic management for different cancer types.

PHF5A 是锌指蛋白的成员。为了加深对它们在致癌作用中的作用的了解，对不同肿瘤发生的实验研究、动物模型和临床研究的数据进行了回顾。此外，PHF5A 作为一种致癌功能，经常在肿瘤细胞中高表达，并且是不同癌症的潜在预后标志物。 PHF5A 参与癌细胞增殖、侵袭、迁移和转移的调节。 PHF5A的敲低阻止了肿瘤细胞的侵袭和转移。本文结合近期文献对 PHF5A 在不同癌症中的作用及其可能的机制进行了回顾和讨论。他们对不同癌症类型的治疗管理有一个开放的有希望的前景。