Abstract

Ring opening in 2-[(2-oxofuran-3(2H)-yliden)amino]-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitriles under the action of various nitriles and t-BuOK was used to synthesize previously unknown substituted potassium 1-cyano-3-{(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)amino}-5-oxopenta-1,3-dien-2-olates. The structure of the obtained compounds was confirmed by ¹H and ¹³C NMR spectroscopy and elemental analysis. The anticoagulant activity of the products was studied.

中文翻译：

---

取代钾1-氰基-3-{(3-氰基-4,5,6,7-四氢苯并[b]噻吩-2-基)氨基}-5-氧代戊二烯-1,3-二烯-的合成及止血活性2-油酸盐

摘要

2-[(2-氧代呋喃-3(2H ) -亚基)氨基]-4,5,6,7-四氢苯并[ b ]噻吩-3-甲腈在各种腈和t -BuOK的作用下开环用于合成以前未知的取代钾 1-cyano-3-{(3-cyano-4,5,6,7-tetraHydroBenz[ b ]thiophen-2-yl)amino}-5-oxopenta-1,3-dien- 2-油酸盐。所得化合物的结构通过¹ H 和¹³ C NMR 光谱和元素分析进行​​了确认。研究了产物的抗凝血活性。