Scientific Reports ( IF 3.8 ) Pub Date : 2023-11-14 , DOI: 10.1038/s41598-023-46435-y Shuqing Li 1 , Zhihui Yi 1 , Mingqing Li 1 , Zhiling Zhu 1
The present study aimed to evaluate the effects of radiotherapy on the overall survival of patients with primary stage IA, grade I–III uterine endometrioid carcinoma or stage IB, grade I–II uterine endometrioid carcinoma. A total of 7504 patients with stage IA, grade I–III uterine endometrioid carcinoma, and 857 patients with stage IB, grade I–II uterine endometrioid carcinoma were collected for the present study. Following propensity score matching (PSM), statistical analysis was performed for the equalized number of patients with stage IA, grade I–III uterine endometrioid carcinoma (n = 383) and patients with stage IB, grade I–II uterine endometrioid carcinoma (n = 330). For patients with primary stage IA, grade I–III uterine endometrioid carcinoma, radiotherapy was found to promoted a reduced 5-year overall survival rates [hazard ratio (HR), 1.726; 95% confidence interval (CI), 1.456–2.046; P < 0.05]. In patients with primary stage IB, grade I–II uterine endometrioid carcinoma, no significant differences were observed in the 5-year overall survival rates between radiotherapy and no radiotherapy groups (P = 0.059). In conclusion, radiotherapy may not improve 5-year overall survival for patients with primary stage IA, grade I–III or stage IB, grade I–II uterine endometrioid carcinoma.
中文翻译:
放疗对IA期和低级别IB期子宫内膜样癌患者生存的影响
本研究旨在评估放疗对原发性IA期、I-III级子宫内膜样癌或IB期、I-II级子宫内膜样癌患者总体生存的影响。本研究共收集了 7504 例 IA 期、I-III 级子宫内膜样癌患者和 857 例 IB 期、I-II 级子宫内膜样癌患者。倾向评分匹配 (PSM) 后,对 IA 期、I-III 级子宫内膜样癌患者 (n = 383) 和 IB 期、I-II 级子宫内膜样癌患者 (n = 383) 的均衡人数进行统计分析330)。对于原发性 IA 期、I-III 级子宫内膜样癌患者,放疗被发现可降低 5 年总生存率 [风险比 (HR),1.726; 95% 置信区间 (CI),1.456–2.046; P<0.05]。在原发性IB期、I-II级子宫内膜样癌患者中,放疗组和未放疗组的5年总生存率没有显着差异(P = 0.059)。总之,放疗可能无法改善原发性 IA 期、I-III 级或 IB 期、I-II 级子宫内膜样癌患者的 5 年总生存率。