Multifaceted Applications of Ferritin Nanocages in Delivering Metal Ions, Bioactive Compounds, and Enzymes: A Comprehensive Review,Journal of Agricultural and Food Chemistry

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Multifaceted Applications of Ferritin Nanocages in Delivering Metal Ions, Bioactive Compounds, and Enzymes: A Comprehensive Review
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2023-11-13 , DOI: 10.1021/acs.jafc.3c05510
Jiangnan Hu ₁ , Xinmei Sha ₁ , Yue Li ₁ , Jincan Wu ₁ , Junrui Ma ₁ , Yuyu Zhang ₂ , Rui Yang ₁

Affiliation

Ferritin, a distinctive iron-storage protein, possesses a unique cage-like nanoscale structure that enables it to encapsulate and deliver a wide range of biomolecules. Recent advances prove that ferritin can serve as an efficient 8 nm diameter carrier for various bioinorganic nutrients, such as minerals, bioactive polyphenols, and enzymes. This review offers a comprehensive summary of ferritin’s structural features from different sources and emphasizes its functions in iron supplementation, calcium delivery, single- and coencapsulation of polyphenols, and enzyme package. Additionally, the influence of innovative food processing technologies, including manothermosonication, pulsed electric field, and atmospheric cold plasma, on the structure and function of ferritin are examined. Furthermore, the limitations and prospects of ferritin in food and nutritional applications are discussed. The exploration of ferritin as a multifunctional protein with the capacity to load various biomolecules is crucial to fully harnessing its potential in food applications.

中文翻译：

铁蛋白纳米笼在传递金属离子、生物活性化合物和酶方面的多方面应用：综合综述

铁蛋白是一种独特的储铁蛋白，具有独特的笼状纳米级结构，使其能够封装和输送多种生物分子。最近的进展证明，铁蛋白可以作为各种生物无机营养素（例如矿物质、生物活性多酚和酶）的有效 8 nm 直径载体。本综述全面总结了不同来源的铁蛋白的结构特征，并强调了其在补铁、钙输送、多酚单胶囊和共胶囊以及酶包装方面的功能。此外，还研究了创新食品加工技术（包括热超声处理、脉冲电场和常压冷等离子体）对铁蛋白结构和功能的影响。此外，还讨论了铁蛋白在食品和营养应用中的局限性和前景。探索铁蛋白作为一种具有负载各种生物分子能力的多功能蛋白质对于充分发挥其在食品应用中的潜力至关重要。

更新日期：2023-11-13

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