Evaluating impacts of bambusuril pocket size and sterics on anion binding trends using ChemFET sensors,Organic & Biomolecular Chemistry

当前位置： X-MOL 学术 › Org. Biomol. Chem. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Evaluating impacts of bambusuril pocket size and sterics on anion binding trends using ChemFET sensors
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2023-11-13 , DOI: 10.1039/d3ob01781h
Douglas H Banning ₁ , Grace M Kuhl ₁ , Madeline M Howell ₁ , Darren W Johnson ₁

Affiliation

Chemically-sensitive Field Effect Transistors (ChemFETs) are a useful tool to evaluate aqueous anion affinity of hydrophobic supramolecular scaffolds. More specifically, ChemFETs can be used to probe impacts of receptor modification to aqueous anion affinity. In this study, ChemFETs are used to evaluate the anion affinity of both dodeca-n-butyl bambus[6]uril and dodecabenzyl bambus[6]uril to assess steric effects in the chemical selectivity of the sensor membrane. The ChemFETs were evaluated through a series of common anions in the Hofmeister series in order to ascertain the difference in detection limit imparted by the specific functionalization of the bambus[6]uril macrocycles, which are quite sensitive to modest steric effects. Significant improvements to perchlorate and nitrate detection limits were observed via n-butyl bambusuril-containing sensor membranes over detection limits recorded with benzyl bambusuril sensors.

中文翻译：

使用 ChemFET 传感器评估班巴脲袋尺寸和空间位阻对阴离子结合趋势的影响

化学敏感场效应晶体管 (ChemFET) 是评估疏水性超分子支架的水阴离子亲和力的有用工具。更具体地说，ChemFET 可用于探测受体修饰对水性阴离子亲和力的影响。在本研究中，ChemFET 用于评估十二烷正丁基竹脲 [6] 和十二苄基竹脲 [6] 的阴离子亲和力，以评估传感器膜化学选择性的空间效应。通过 Hofmeister 系列中的一系列常见阴离子对 ChemFET 进行了评估，以确定对适度空间效应非常敏感的 bambus[6]uril 大环的特定功能化所带来的检测限差异。通过含有正丁基竹脲的传感器膜，观察到高氯酸盐和硝酸盐的检测限显着提高，超过使用苄基竹脲传感器记录的检测限。

更新日期：2023-11-13

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南