基于纳米技术的和厚朴给药系统：增强治疗潜力并克服局限性,International Journal of Nanomedicine

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基于纳米技术的和厚朴给药系统：增强治疗潜力并克服局限性
International Journal of Nanomedicine ( IF 6.6 ) Pub Date : 2023-11-13 , DOI: 10.2147/ijn.s431409
Jing Yang _{1,

2} , Jinlu Shang _{1,

2} , Liuxuan Yang _{1,

2} , Daiqing Wei ₃ , Xia Wang ₁ , Qinmin Deng ₂ , Zhirong Zhong ₄ , Yun Ye ₁ , Meiling Zhou ₁

Affiliation

摘要：和厚朴酚（HNK）是一种小分子多酚，因其具有抗肿瘤、抗炎、抗菌、抗肥胖等多种药理特性而受到广泛关注。然而，其临床应用受到溶解度低、生物利用度差、代谢快等挑战的限制。为了克服这些限制，研究人员开发了多种用于 HNK 递送的纳米制剂。这些纳米制剂具有增强溶解度、提高生物利用度、延长循环时间和靶向药物输送等优点。然而，现有对HNK的综述主要集中于其临床和药理特征，对基于纳米技术的HNK递送系统的综合评价存在空白。本文旨在通过全面回顾过去 15 年用于 HNK 递送的不同类型的纳米材料来弥补这一差距。这些材料包括囊泡递送系统、纳米颗粒、聚合物胶束、纳米凝胶和各种其他纳米载体。该论文详细介绍了各种 HNK 纳米递送策略，并总结了它们的最新应用、发展前景和未来的挑战。为了撰写这篇综述，我们使用“和厚朴酚”、“纳米技术”和“药物输送系统”等关键词在 PubMed、Scopus 和 Web of Science 等知名数据库上进行了广泛的搜索，检索时间范围为 2008 年至 2023 年。通过这次搜索，我们确定并选择了大约 90 篇符合我们特定标准的文章。

关键词:和厚朴酚, 纳米技术, 药物递送, 靶向, 抗肿瘤, 生物利用度

"点击查看英文标题和摘要"

Nanotechnology-Based Drug Delivery Systems for Honokiol: Enhancing Therapeutic Potential and Overcoming Limitations

Abstract: Honokiol (HNK) is a small-molecule polyphenol that has garnered considerable attention due to its diverse pharmacological properties, including antitumor, anti-inflammatory, anti-bacterial, and anti-obesity effects. However, its clinical application is restricted by challenges such as low solubility, poor bioavailability, and rapid metabolism. To overcome these limitations, researchers have developed a variety of nano-formulations for HNK delivery. These nano-formulations offer advantages such as enhanced solubility, improved bioavailability, extended circulation time, and targeted drug delivery. However, existing reviews of HNK primarily focus on its clinical and pharmacological features, leaving a gap in the comprehensive evaluation of HNK delivery systems based on nanotechnology. This paper aims to bridge this gap by comprehensively reviewing different types of nanomaterials used for HNK delivery over the past 15 years. These materials encompass vesicle delivery systems, nanoparticles, polymer micelles, nanogels, and various other nanocarriers. The paper details various HNK nano-delivery strategies and summarizes their latest applications, development prospects, and future challenges. To compile this review, we conducted an extensive search using keywords such as “honokiol”, “nanotechnology”, and “drug delivery system” on reputable databases, including PubMed, Scopus, and Web of Science, covering the period from 2008 to 2023. Through this search, we identified and selected approximately 90 articles that met our specific criteria.

Keywords: honokiol, nanotechnology, drug delivery, targeting, antitumor, bioavailability

更新日期：2023-11-13

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