Enzymatic Fluoromethylation as a Tool for ATP-Independent Ligation,Angewandte Chemie International Edition

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Enzymatic Fluoromethylation as a Tool for ATP-Independent Ligation
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2023-11-13 , DOI: 10.1002/anie.202312104
Jiaming Peng ₁ , Gregory R Hughes ₂ , Manuel M Müller ₂ , Florian P Seebeck ₁

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This report shows that methyltransferase-mediated fluoromethylation can activate small and large carboxylate substrates for conjugation to thiols, hydrazine, hydroxylamine or amines. This methodology to produce anhydrides offers an alternative to the much more common ATP-dependent processes observed in nature and utilized in biocatalysis.

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