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Enzymatic Fluoromethylation as a Tool for ATP-Independent Ligation
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2023-11-13 , DOI: 10.1002/anie.202312104
Jiaming Peng 1 , Gregory R Hughes 2 , Manuel M Müller 2 , Florian P Seebeck 1
Affiliation  

This report shows that methyltransferase-mediated fluoromethylation can activate small and large carboxylate substrates for conjugation to thiols, hydrazine, hydroxylamine or amines. This methodology to produce anhydrides offers an alternative to the much more common ATP-dependent processes observed in nature and utilized in biocatalysis.

中文翻译:


酶促氟甲基化作为不依赖 ATP 的连接工具



该报告表明,甲基转移酶介导的氟甲基化可以激活小型和大型羧酸酯底物,以与硫醇、肼、羟胺或胺缀合。这种生产酸酐的方法为自然界中观察到并用于生物催化的更常见的 ATP 依赖性过程提供了一种替代方案。
更新日期:2023-11-13
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