A Multifunctional Hydrogel for Simultaneous Visible H2O2 Monitoring And Accelerating Diabetic Wound Healing,Advanced Healthcare Materials

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A Multifunctional Hydrogel for Simultaneous Visible H2O2 Monitoring And Accelerating Diabetic Wound Healing
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2023-10-12 , DOI: 10.1002/adhm.202302328
Jimin Huang _{1,

2} , Yi Zheng _{1,

2} , Huicong Niu _{1,

3} , Jinzhou Huang _{1,

2} , XinXin Zhang _{1,

2} , Jiajie Chen _{1,

2} , Bing Ma _{1,

2} , Chengtie Wu _{1,

2} , Yi Cao ₄ , Yufang Zhu _{1,

2}

Affiliation

Diabetic wound is one of the chronic wounds that is difficult to heal, and effective treatment of it still confronts a great challenge. Monitoring the variation of diabetic wound microenvironment (such as hydrogen peroxide (H₂O₂)) can understand the wound state and guide the wound management. Herein, a multifunctional hydrogel with the abilities of monitoring the H₂O₂ concentration, alleviating oxidative stress and promoting wound healing is developed, which is prepared by encapsulating manganese-containing bioactive glass (MnBG) and CePO₄:Tb in biocompatible gelatin methacryloyl (GelMA) hydrogel (CPT-MnBG-Gel). On the one hand, the H₂O₂-dependent fluorescence quenching effect of the CePO₄:Tb contributes to visible monitoring of the H₂O₂ concentration of wounds via smartphone imaging, and the CPT-MnBG-Gel hydrogel can effectively monitor the H₂O₂ level of 10.35–200 µmol L⁻¹. On the other hand, MnBG can alleviate oxidative stress and promote the proliferation, migration and differentiation of fibroblasts and endothelial cells in vitro owing to the bioactive Mn and Si ions, and in vivo evaluation also demonstrates that the CPT-MnBG-Gel hydrogels can effectively accelerate wound healing. Hence, such multifunctional hydrogel is promising for diabetic wound management and accelerating wound healing.

中文翻译：

用于同时可见 H2O2 监测和加速糖尿病伤口愈合的多功能水凝胶

糖尿病伤口是难以愈合的慢性伤口之一，其有效治疗仍面临很大挑战。监测糖尿病伤口微环境（如过氧化氢（H ₂ O ₂ ））的变化可以了解伤口状态并指导伤口处理。本文开发了一种具有监测H ₂ O ₂浓度、减轻氧化应激和促进伤口愈合能力的多功能水凝胶，该水凝胶是通过将含锰生物活性玻璃（MnBG）和CePO ₄ :Tb封装在生物相容性明胶甲基丙烯酰中制备而成。 GelMA）水凝胶（CPT-MnBG-Gel）。一方面，CePO ₄ :Tb 的 H ₂ O ₂依赖性荧光猝灭效应有助于通过智能手机成像对伤口的 H ₂ O 2 浓度进行可见监测，而 CPT-MnBG-Gel 水凝胶可以有效监测伤口的 H 2 O ₂浓度。 H ₂ O ₂水平为10.35–200 µmol L ^-1 。另一方面，由于具有生物活性的Mn和Si离子，MnBG可以在体外缓解氧化应激并促进成纤维细胞和内皮细胞的增殖、迁移和分化，体内评价也表明CPT-MnBG-Gel水凝胶可以有效地抑制氧化应激。加速伤口愈合。因此，这种多功能水凝胶有望用于糖尿病伤口管理和加速伤口愈合。

更新日期：2023-10-12

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