<br>circRNA在中枢神经系统肿瘤发生发展中的调控作用及临床应用前景,CNS Neuroscience & Therapeutics

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circRNA在中枢神经系统肿瘤发生发展中的调控作用及临床应用前景
CNS Neuroscience & Therapeutics ( IF 4.8 ) Pub Date : 2023-11-12 , DOI: 10.1111/cns.14500
Bo Zhang _{1,

2} , Hao Zhang _{1,

3} , Zeyu Wang _{1,

4} , Hui Cao ₅ , Nan Zhang ₆ , Ziyu Dai _{1,

2} , Xisong Liang _{1,

2} , Yun Peng _{7,

8} , Jie Wen _{1,

2} , Xun Zhang _{1,

2} , Liyang Zhang _{1,

2} , Peng Luo ₉ , Jian Zhang ₉ , Zaoqu Liu ₁₀ , Quan Cheng _{1,

2} , Renjun Peng _{1,

2}

Affiliation

Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China.
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
Department of Neurosurgery, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
MRC Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.
Department of Psychiatry, The School of Clinical Medicine, Hunan University of Chinese Medicine, Changsha, China.
College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China.
Teaching and Research Section of Clinical Nursing, Xiangya Hospital of Central South University, Changsha, China.
Department of Geriatrics, Xiangya Hospital, Central South University, Changsha, China.
Department of Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

中枢神经系统（CNS）肿瘤起源于脊髓或大脑。研究表明，即使采取积极治疗，恶性中枢神经系统肿瘤的死亡率也很高。然而，中枢神经系统肿瘤的危险因素和分子机制尚未得到验证。由于上述原因，目前中枢神经系统肿瘤的诊断和治疗在临床上面临着困难。环状RNA（circRNA）是具有共价闭合连续结构的单链ncRNA，对于中枢神经系统肿瘤的发展至关重要。越来越多的证据证明了 circRNA 对疾病进展的重要生物学功能：海绵作用于 miRNA、调节基因转录和剪接、与蛋白质相互作用、编码蛋白质/肽以及在外泌体中表达。

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更新日期：2023-11-13

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