Because few studies have identified biological factors that predict the persistence of eating pathology, we tested the hypotheses that elevated responsivity of brain regions implicated in reward valuation to thin models and high-calorie binge foods would predict the persistence of eating pathology. We analyzed data from 146 women (Mage = 21.87 ± 3.81) with threshold or subthreshold anorexia nervosa, bulimia nervosa, binge eating disorder, or purging disorder who completed functional magnetic resonance imaging scans assessing neural response to thin models and binge foods at baseline, were randomized to two eating disorder treatments or a waitlist control condition and completed diagnostic interviews that assessed change in symptoms over 2.5-month follow-up. Elevated activation in regions associated with memory (parahippocampal gyrus r = .38; hippocampus r = .25) and with reward valuation and emotional salience (amygdala r = .35) in response to thin versus average-weight models predicted future persistence of an eating disorder symptom composite (all analyses controlled for treatment condition). Neural response to high-calorie binge foods did not predict the persistence of eating disorder symptoms. There was no evidence that either treatment moderated the relation of baseline neural responsivity to thin models to future persistence of eating disorder symptoms, though power for these post hoc analyses was limited. Results suggest that overvaluation of the thin ideal increases the risk for the persistence of eating disorder symptoms but provided no support for the hypothesis that overvaluation of high-calorie foods would predict symptom persistence. Results imply that treatments should seek to reduce the overvaluation of the thin ideal. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

中文翻译：

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对瘦模型的奖励、情绪和记忆区域反应升高可预测饮食失调症状的持续性：一项前瞻性功能磁共振成像研究。

由于很少有研究发现可以预测饮食病理学持续存在的生物学因素，因此我们测试了以下假设：提高与瘦模型和高热量暴食食物的奖励评估有关的大脑区域的反应性可以预测饮食病理学的持续存在。我们分析了 146 名患有阈值或阈下神经性厌食症、神经性贪食症、暴食症或清除障碍的女性 (Mage = 21.87 ± 3.81) 的数据，这些女性完成了功能性磁共振成像扫描，评估了基线时对瘦模型和暴食食物的神经反应，随机接受两种饮食失调治疗或候补控制条件，并完成诊断访谈，评估 2.5 个月随访期间症状的变化。与记忆相关的区域（海马旁回 r = .38；海马 r = .25）以及与奖励评价和情绪显着性（杏仁核 r = .35）相关的区域的激活程度升高，以响应瘦身模型与平均体重模型，预测未来的饮食持续性疾病症状组合（所有分析均针对治疗条件进行控制）。对高热量暴食食物的神经反应并不能预测饮食失调症状的持续存在。没有证据表明这两种治疗方法可以调节瘦模型的基线神经反应与未来饮食失调症状持续存在的关系，尽管这些事后分析的力量有限。结果表明，对瘦身理想的高估会增加饮食失调症状持续存在的风险，但没有为高热量食物的高估会预测症状持续的假设提供支持。结果表明，治疗应寻求减少对瘦身理想的高估。（PsycInfo 数据库记录 (c) 2023 APA，保留所有权利）。