Kaempferol-3-O-sophoroside (PCS-1) contributes to modulation of depressive-like behaviour in C57BL/6J mice by activating AMPK,British Journal of Pharmacology

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Kaempferol-3-O-sophoroside (PCS-1) contributes to modulation of depressive-like behaviour in C57BL/6J mice by activating AMPK
British Journal of Pharmacology ( IF 6.8 ) Pub Date : 2023-11-10 , DOI: 10.1111/bph.16283
Rong Wang ₁ , Xiaolong Hu ₁ , Shumeng Liu ₁ , Jingjin Wang ₁ , Fei Xiong ₂ , Xiaoqi Zhang ₃ , Wencai Ye ₃ , Hao Wang ₁

Affiliation

Kaempferol-3-O-sophoroside (PCS-1) is the main component in Crocus sativus (Saffron), a herb with mood-enhancing properties. AMP-activated protein kinase (AMPK) is a potential therapeutic target for depression. This study explores the antidepressive-like properties of PCS-1 and its AMPK activation to confirm AMPK as a target for antidepression.

中文翻译：

Kaempferol-3-O-sophoroside (PCS-1) 通过激活 AMPK 有助于调节 C57BL/6J 小鼠的抑郁样行为

Kaempferol-3- O -sophoroside ( PCS-1 ) 是番红花（藏红花）的主要成分，番红花是一种具有增强情绪特性的草药。AMP 激活蛋白激酶 (AMPK) 是抑郁症的潜在治疗靶点。本研究探讨了PCS-1的抗抑郁样特性及其 AMPK 激活，以确认 AMPK 作为抗抑郁的靶点。

更新日期：2023-11-10

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