Disulfide Click Reaction for Stapling of S-terminal Peptides,Angewandte Chemie International Edition

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Disulfide Click Reaction for Stapling of S-terminal Peptides
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2023-11-10 , DOI: 10.1002/anie.202314379
Qing Yu ₁ , Leiyang Bai ₁ , Xuefeng Jiang _{1,

2,

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Affiliation

A library of disulfide linkers was established for Cys−Cys−(Cys) double/triple click stapling in only 1 min, bridging from 3 to 18 amino acid residues to deliver 18- to 48-membered locked peptides. The opposite unstapling process proceeded smoothly, making the reversible cross-linking reagents potentially suitable for peptide delivery.

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