Succinate is a pro-inflammatory citric acid cycle metabolite that accumulates in tissues during pathophysiological states. Oxidation of succinate after ischemia-reperfusion leads to reversal of the electron transport chain and generation of reactive oxygen species. Dimethyl malonate (DMM) is a competitive inhibitor of succinate dehydrogenase, which has been shown to reduce succinate accumulation. We hypothesized that DMM would protect against inflammation in a murine model of ARDS.

中文翻译：

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丙二酸二甲酯可保护急性呼吸窘迫综合征小鼠模型中的肺。

琥珀酸是一种促炎柠檬酸循环代谢物，在病理生理状态下在组织中积累。缺血再灌注后琥珀酸的氧化导致电子传递链逆转并产生活性氧。丙二酸二甲酯 (DMM) 是琥珀酸脱氢酶的竞争性抑制剂，已被证明可以减少琥珀酸积累。我们假设 DMM 可以预防 ARDS 小鼠模型中的炎症。