用于精准医学的无束缚微夹具,Small

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用于精准医学的无束缚微夹具
Small ( IF 13.0 ) Pub Date : 2023-11-08 , DOI: 10.1002/smll.202305805
Huaijuan Zhou ₁ , Shengchang Zhang ₂ , Zijian Liu ₂ , Bowen Chi ₃ , Jinhua Li ₂ , Yilong Wang _{2,

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Affiliation

微抓手是微纳米机器人的一个分支，是指尺寸在几微米到几百微米范围内的可运动的微型机器。与系留式夹具或其他显微诊断和手术设备相比，无系留式微夹具因其尺寸小型化、灵巧的形状变换和可控运动等特点，使得微夹具能够进入难以到达的区域，在生物医学应用中发挥着不可或缺的作用。执行疾病诊断和治疗的特定医疗任务。迄今为止，已经开发了许多医用微夹具，并探索了它们在细胞操作、靶向药物输送、活检和微创手术中的潜力。为了实现受控运动和有效的目标导向行动，应精心设计微夹具的材料、尺寸、微结构和形态。在这篇综述中，作者总结了无束缚微米级夹具的最新进展。首先介绍了变形的工作机制和有效运动的驱动方法。然后，讨论了微夹具的设计原理和最先进的制造技术。最后，重点介绍了它们在精准医学中的应用，并为无线医疗微夹具的发展提供了未来的前景。

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Untethered Microgrippers for Precision Medicine

Microgrippers, a branch of micro/nanorobots, refer to motile miniaturized machines that are of a size in the range of several to hundreds of micrometers. Compared with tethered grippers or other microscopic diagnostic and surgical equipment, untethered microgrippers play an indispensable role in biomedical applications because of their characteristics such as miniaturized size, dexterous shape tranformation, and controllable motion, which enables the microgrippers to enter hard-to-reach regions to execute specific medical tasks for disease diagnosis and treatment. To date, numerous medical microgrippers are developed, and their potential in cell manipulation, targeted drug delivery, biopsy, and minimally invasive surgery are explored. To achieve controlled locomotion and efficient target-oriented actions, the materials, size, microarchitecture, and morphology of microgrippers shall be deliberately designed. In this review, the authors summarizes the latest progress in untethered micrometer-scale grippers. The working mechanisms of shape-morphing and actuation methods for effective movement are first introduced. Then, the design principle and state-of-the-art fabrication techniques of microgrippers are discussed. Finally, their applications in the precise medicine are highlighted, followed by offering future perspectives for the development of untethered medical microgrippers.

更新日期：2023-11-08

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