Flexible organic bioelectronic devices, which extract electronic signals from living systems, have been developed for sensing, recording, and monitoring various physiological states of biological systems. Organic electrochemical transistors (OECTs) have emerged as a promising platform for bioelectronics because of their inherent amplification function, high sensitivity, low cost, easy operation, and compatibility with flexible and wearable devices. This review provides a comprehensive overview of recent advancements in flexible OECTs for biosensing applications, including the fundamental principles and mechanisms of flexible OECTs, various channel materials used for biosensing, functionalization of OECTs for biosensing, use of flexible OECTs for the acquisition of biological signals, bioinformatics analysis of OECT-based biosensors, and development of biomimetic devices. The review concludes with a summary of the state-of-the-art technology for flexible OECT-based biosensors and the future outlook for this rapidly evolving field.

柔性有机生物电子器件可以从生命系统中提取电子信号，用于感测、记录和监测生物系统的各种生理状态。有机电化学晶体管（OECT）因其固有的放大功能、高灵敏度、低成本、易于操作以及与柔性和可穿戴设备的兼容性而成为生物电子学的一个有前途的平台。该综述全面概述了柔性OECT在生物传感应用中的最新进展，包括柔性OECT的基本原理和机制、用于生物传感的各种通道材料、用于生物传感的OECT的功能化、使用柔性OECT采集生物信号、基于 OECT 的生物传感器的生物信息学分析以及仿生设备的开发。该评论最后总结了基于 OECT 的灵活生物传感器的最先进技术以及这个快速发展领域的未来前景。