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Signal Modulation of Organic Photoelectrochemical Transistor by a Z-Scheme Photocathodic Gate: An Innovative Dual Amplification Strategy for Sensitive Aptasensing Application
Analytical Chemistry ( IF 6.7 ) Pub Date : 2023-11-10 , DOI: 10.1021/acs.analchem.3c04258 Qian Liu 1, 2 , Zhijie Guo 1 , Xiuli Hou 1 , Guoping Huang 2 , Tianyan You 1
Analytical Chemistry ( IF 6.7 ) Pub Date : 2023-11-10 , DOI: 10.1021/acs.analchem.3c04258 Qian Liu 1, 2 , Zhijie Guo 1 , Xiuli Hou 1 , Guoping Huang 2 , Tianyan You 1
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Pursuing a more efficient signal amplification strategy is highly demanded for improving the performance of the promising cathodic photoelectrochemical (PEC) sensors. In this work, we present an extremely effective dual signal amplification strategy by the integration of a Z-scheme nanohybrids-based photocathode with the effective signal modulation of an organic photoelectrochemical transistor (OPECT) device. Specifically, photocathodic gate material of CdTe–BiOBr nanohybrids with a Z-scheme electron-transfer route was designed and synthesized for preliminary improvement of the activity of the photogate; afterward, signal modulation of the OPECT system by the photocathodic gate of CdTe–BiOBr was then accomplished for further signal amplification by 2 orders of magnitude. As a result, the output PEC signal of CdTe–BiOBr was enhanced by 17.5-fold as compared to BiOBr, and the channel current (IDS) of the OPECT device was 117-fold magnified than its gate current (IG) response. Exemplified by tetracycline (TC) as a model target and aptamer as the specific recognition element, a versatile cathodic aptasensing platform was constructed based on the proposed OPECT device. The introduced OPECT aptasensor merits advantages, including a good linear range (1.0 × 10–12 to 1.0 × 10–6 M), a low limit of detection (4.2 × 10–13 M), and superior sensitivity than the traditional PEC methods for TC detection, which represents a universal protocol for developing the innovative photocathodic OPECT sensing platform toward accurate analysis.
中文翻译：
Z 型光阴极门对有机光电化学晶体管的信号调制：一种用于灵敏适体传感应用的创新双放大策略
为了提高有前途的阴极光电化学（PEC）传感器的性能，迫切需要追求更有效的信号放大策略。在这项工作中，我们通过将基于Z型纳米混合体的光电阴极与有机光电化学晶体管 (OPECT) 器件的有效信号调制相集成，提出了一种极其有效的双信号放大策略。具体而言，设计并合成了具有Z型电子转移路径的CdTe-BiOBr纳米杂化物光阴极栅极材料，初步提高了光电栅极的活性；随后，通过 CdTe-BiOBr 光电阴极门对 OPECT 系统进行信号调制，进一步将信号放大 2 个数量级。结果，与 BiOBr 相比，CdTe-BiOBr 的输出 PEC 信号增强了 17.5 倍，并且 OPECT 器件的沟道电流（ I DS ）比其栅极电流（ I G ）响应放大了 117 倍。以四环素（TC）作为模型靶点和适体作为特异性识别元件，基于所提出的 OPECT 装置构建了多功能阴极适体传感平台。所推出的 OPECT 适体传感器具有良好的线性范围（1.0 × 10 –12至 1.0 × 10 –6 M）、低检测限（4.2 × 10 –13 M）以及比传统 PEC 方法更高的灵敏度等优点。 TC 检测，它代表了开发创新型光电阴极 OPECT 传感平台以实现精确分析的通用协议。
更新日期：2023-11-10
中文翻译：
Z 型光阴极门对有机光电化学晶体管的信号调制：一种用于灵敏适体传感应用的创新双放大策略
为了提高有前途的阴极光电化学（PEC）传感器的性能，迫切需要追求更有效的信号放大策略。在这项工作中，我们通过将基于Z型纳米混合体的光电阴极与有机光电化学晶体管 (OPECT) 器件的有效信号调制相集成，提出了一种极其有效的双信号放大策略。具体而言，设计并合成了具有Z型电子转移路径的CdTe-BiOBr纳米杂化物光阴极栅极材料，初步提高了光电栅极的活性；随后，通过 CdTe-BiOBr 光电阴极门对 OPECT 系统进行信号调制，进一步将信号放大 2 个数量级。结果，与 BiOBr 相比，CdTe-BiOBr 的输出 PEC 信号增强了 17.5 倍，并且 OPECT 器件的沟道电流（ I DS ）比其栅极电流（ I G ）响应放大了 117 倍。以四环素（TC）作为模型靶点和适体作为特异性识别元件，基于所提出的 OPECT 装置构建了多功能阴极适体传感平台。所推出的 OPECT 适体传感器具有良好的线性范围（1.0 × 10 –12至 1.0 × 10 –6 M）、低检测限（4.2 × 10 –13 M）以及比传统 PEC 方法更高的灵敏度等优点。 TC 检测，它代表了开发创新型光电阴极 OPECT 传感平台以实现精确分析的通用协议。
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