Bioresorbable bioelectronics, with their natural degradation properties, hold significant potential to eliminate the need for surgical removal. Despite notable achievements, two major challenges hinder their practical application in medical settings. First, they necessitate sustainable energy solutions with biodegradable components via biosafe powering mechanisms. More importantly, reliability in their function is undermined by unpredictable device lifetimes due to the complex polymer degradation kinetics. Here, we propose an on-demand bioresorbable neurostimulator to address these issues, thus allowing for clinical operations to be manipulated using biosafe ultrasound sources. Our ultrasound-mediated transient mechanism enables (1) electrical stimulation through transcutaneous ultrasound-driven triboelectricity and (2) rapid device elimination using high-intensity ultrasound without adverse health effects. Furthermore, we perform neurophysiological analyses to show that our neurostimulator provides therapeutic benefits for both compression peripheral nerve injury and hereditary peripheral neuropathy. We anticipate that the on-demand bioresorbable neurostimulator will prove useful in the development of medical implants to treat peripheral neuropathy.

生物可吸收生物电子学具有自然降解特性，具有消除手术切除需要的巨大潜力。尽管取得了显着的成就，但两大挑战阻碍了它们在医疗环境中的实际应用。首先，他们需要通过生物安全供电机制采用可生物降解成分的可持续能源解决方案。更重要的是，由于复杂的聚合物降解动力学，其功能的可靠性受到不可预测的器件寿命的影响。在这里，我们提出了一种按需生物可吸收神经刺激器来解决这些问题，从而允许使用生物安全超声源来操纵临床手术。我们的超声介导的瞬态机制能够（1）通过经皮超声驱动的摩擦电进行电刺激，以及（2）使用高强度超声快速消除设备，而不会对健康产生不利影响。此外，我们进行神经生理学分析，以表明我们的神经刺激器对压迫性周围神经损伤和遗传性周围神经病都有治疗效果。我们预计，按需生物可吸收神经刺激器将在开发治疗周围神经病变的医疗植入物中发挥作用。