Targeted delivery of LXR-agonists to atherosclerotic lesions mediated by polydiacetylene micelles,Nanoscale

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Targeted delivery of LXR-agonists to atherosclerotic lesions mediated by polydiacetylene micelles
Nanoscale ( IF 5.8 ) Pub Date : 2023-11-09 , DOI: 10.1039/d3nr04778d
Lucie Jamgotchian ₁ , Laurent Devel ₂ , Robert Thai ₂ , Lucie Poupel ₃ , Thierry Huby ₄ , Emmanuel Gautier ₄ , Wilfried Le Goff ₄ , Philippe Lesnik ₄ , Edmond Gravel ₁ , Eric Doris ₁

Affiliation

We report the development of compact and stabilized micelles incorporating a synthetic LXR agonist prodrug for the passive targeting of atherosclerotic lesions and therapeutic intervention. In vivo studies showed that the nanohybrid micelles exhibited favorable pharmacokinetics/biodistribution and were able to upregulate, to some extent, LXR target genes with no alteration of lipid metabolism.

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