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Coffee Leaf Tea Extracts Improve Hyperuricemia Nephropathy and Its Associated Negative Effect in Gut Microbiota and Amino Acid Metabolism in Rats
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2023-11-07 , DOI: 10.1021/acs.jafc.3c02797 Xiaofei Zhou 1, 2 , Bowei Zhang 1 , Xiuli Zhao 2 , Pixian Zhang 2 , Jingting Guo 2 , Yuan Zhuang 2 , Shuo Wang 1
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2023-11-07 , DOI: 10.1021/acs.jafc.3c02797 Xiaofei Zhou 1, 2 , Bowei Zhang 1 , Xiuli Zhao 2 , Pixian Zhang 2 , Jingting Guo 2 , Yuan Zhuang 2 , Shuo Wang 1
Affiliation
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Hyperuricemia nephropathy (HN) is a metabolic disease characterized by tubular damage, tubulointerstitial fibrosis, and uric acid kidney stones and has been demonstrated to be associated with hyperuricemia. Coffee leaf tea is drunk as a functional beverage. However, its prevention effects on HN remain to be explored. This study showed that coffee leaf tea extracts (TE) contain 19 polyphenols, with a total content of 550.15 ± 27.58 mg GAE/g. TE decreased serum uric acid levels via inhibiting XOD activities and modulating the expression of urate transporters (GLUT9, OAT3, and ABCG2) in HN rats. TE prevented HN-induced liver and kidney damage and attenuated renal fibrosis. Moreover, it upregulated the abundance of SCFA-producing bacteria (Phascolarctobacterium, Alloprevotella, and Butyricicoccus) in the gut and reversed the amino acid-related metabolism disorder caused by HN. TE also decreased the circulating LPS and d-lactate levels and increased the fecal SCFA levels. This study supported the preliminary and indicative effect of coffee leaf tea in the prevention of hyperuricemia and HN.
中文翻译：
咖啡叶茶提取物改善大鼠高尿酸血症肾病及其对肠道微生物群和氨基酸代谢的相关负面影响
高尿酸血症肾病（HN）是一种以肾小管损伤、肾小管间质纤维化和尿酸性肾结石为特征的代谢性疾病，已被证明与高尿酸血症相关。咖啡叶茶作为功能性饮料饮用。然而，其对 HN 的预防作用仍有待探讨。本研究表明，咖啡叶茶提取物（TE）含有19种多酚，总含量为550.15±27.58 mg GAE/g。TE 通过抑制 HN 大鼠的 XOD 活性和调节尿酸转运蛋白（GLUT9、OAT3 和 ABCG2）的表达来降低血清尿酸水平。TE 可预防 HN 引起的肝肾损伤并减轻肾纤维化。此外，它还上调了肠道中产生 SCFA 的细菌（ Phascolarctobacter、Alloprevotella和Butyricicoccus ）的丰度，并逆转了 HN 引起的氨基酸相关代谢紊乱。TE 还降低了循环 LPS 和d-乳酸水平，并增加了粪便 SCFA 水平。这项研究支持了咖啡叶茶在预防高尿酸血症和 HN 方面的初步和指示性作用。
更新日期：2023-11-07
中文翻译：
咖啡叶茶提取物改善大鼠高尿酸血症肾病及其对肠道微生物群和氨基酸代谢的相关负面影响
高尿酸血症肾病（HN）是一种以肾小管损伤、肾小管间质纤维化和尿酸性肾结石为特征的代谢性疾病，已被证明与高尿酸血症相关。咖啡叶茶作为功能性饮料饮用。然而，其对 HN 的预防作用仍有待探讨。本研究表明，咖啡叶茶提取物（TE）含有19种多酚，总含量为550.15±27.58 mg GAE/g。TE 通过抑制 HN 大鼠的 XOD 活性和调节尿酸转运蛋白（GLUT9、OAT3 和 ABCG2）的表达来降低血清尿酸水平。TE 可预防 HN 引起的肝肾损伤并减轻肾纤维化。此外，它还上调了肠道中产生 SCFA 的细菌（ Phascolarctobacter、Alloprevotella和Butyricicoccus ）的丰度，并逆转了 HN 引起的氨基酸相关代谢紊乱。TE 还降低了循环 LPS 和d-乳酸水平，并增加了粪便 SCFA 水平。这项研究支持了咖啡叶茶在预防高尿酸血症和 HN 方面的初步和指示性作用。
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