抗菌MoS2-Ce6-离子液体纳米平台对抗光热/光动力联合治疗和伤口愈合加速,ACS Applied Nano Materials

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抗菌MoS2-Ce6-离子液体纳米平台对抗光热/光动力联合治疗和伤口愈合加速
ACS Applied Nano Materials ( IF 5.3 ) Pub Date : 2023-11-08 , DOI: 10.1021/acsanm.3c02239
Weiwei Zhang ₁ , Xiaokuo Shen ₁ , Wanzhen Li ₁ , Jun Wang ₁ , Zhao Kuang ₁ , Lin Gui ₂ , Yugui Tao ₁ , Ping Song ₁ , Fei Ge ₁ , Longbao Zhu ₁

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耐药细菌感染是人类健康的主要威胁之一。多重耐药（MDR）细菌对传统抗生素治疗的反应并不令人满意。基于光热效应，采用二硫化钼（MoS ₂）纳米颗粒、光敏剂二氢卟酚-e6（Ce6）和离子液体（IL）构建了多功能纳米平台（MoS ₂ -Ce6-IL），该平台对近红外光有响应。 -红外光（880 nm）和可见光（660 nm），具有光热和光动力相结合的抑菌活性。表征实验表明，该纳米平台呈球形，ζ电位为-14.4±1.1 mV，整体粒径约为230 nm，光热转换效率为54%。在这项研究中，该治疗方案对耐多药大肠杆菌（E. coli ）的有效率超过93% ，对金黄色葡萄球菌（S. aureus ）的有效率超过91% 。它能有效抑制MDR细菌，促进感染金黄色葡萄球菌的小鼠皮肤伤口愈合。纳米平台通过破坏细菌细胞膜和DNA，干扰细菌细胞内物质和能量的代谢，最终导致MDR细菌死亡。本研究成功合成了具有显着抑菌活性的多功能纳米系统。阐明了细菌多药耐药的分子机制，为其临床应用奠定了基础。

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Antibacterial MoS2-Ce6-Ionic Liquid Nanoplatform against Photothermal/Photodynamic Combined Therapy and Wound Healing Acceleration

Drug-resistant bacterial infection is one of the major threats to human health. Multidrug-resistant (MDR) bacteria do not respond satisfactorily to conventional antibiotic treatment. Based on the photothermal effect, molybdenum disulfide (MoS₂) nanoparticles, photosensitizer chlorin-e6 (Ce6), and an ionic liquid (IL) were used to construct a multifunctional nanoplatform (MoS₂-Ce6-IL), which is responsive to near-infrared light (880 nm) and visible light (660 nm) with combined photothermal and photodynamic bacteriostatic activity. The characterization experiments revealed that the nanoplatform is spherical, with a ζ potential of −14.4 ± 1.1 mV, an overall particle size of about 230 nm, and a photothermal conversion efficiency of 54%. In this study, the treatment regimen was more than 93% effective against MDR Escherichia coli (E. coli) and more than 91% effective against Staphylococcus aureus (S. aureus). It can effectively inhibit MDR bacteria and promote skin wound healing in mice infected with S. aureus. By destroying the bacterial cell membrane and DNA, the nanoplatform interferes with the metabolism of substances and energy in bacterial cells and ultimately causes the death of MDR bacteria. In this study, a multifunctional nanosystem with remarkable bacteriostatic activity was successfully synthesized. The molecular mechanism of multidrug resistance in bacteria was elucidated, laying the foundation for its clinical application.

更新日期：2023-11-08

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