酰胺键形成的当代方法,Advanced Synthesis & Catalysis

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酰胺键形成的当代方法
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2023-11-07 , DOI: 10.1002/adsc.202301018
Paola Acosta-Guzmán ₁ , Andrea Ojeda-Porras ₁ , Diego Gamba-Sánchez ₁

Affiliation

由于酰胺是生物活性分子中最常见的官能团之一，酰胺键结构近几十年来引起了人们的极大兴趣。在 FDA 2022 年批准的 37 种新药中，有 11 种是含有至少一个酰胺键的小分子。此外，还有十九种大分子被批准为新药，其中一些具有肽结构，因此也带有酰胺键。近年来，多个团队接受了开发更有效的酰胺键形成方法的挑战。这种奉献精神导致每月在著名期刊上发表大量出版物，展示了该领域的重大进步。本次综述的主要目标是提出构建酰胺键的最可行的策略。区分酰胺键形成和酰胺合成至关重要；因此，重点是描述形成新 C(O)−N 键的具体方法。特别是，本次审查集中于过去六年内开发的方法。特别强调在选择起始材料和官能团时考虑思维过程的新方法。这种方法确保覆盖所有产生新酰胺键的最常见的化学转化。

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Contemporary Approaches for Amide Bond Formation

Amide bond construction has garnered significant interest in recent decades due to amides being one of the most prevalent functional groups among bioactive molecules. Out of the thirty-seven new drugs approved by the FDA in 2022, eleven are small molecules containing at least one amide bond. Additionally, there are nineteen large molecules approved as new drugs, some of which have peptide structures, and therefore, also bear amide bonds. In recent years, multiple teams have embraced the challenge of developing more efficient methods for amide bond formation. This dedication has led to numerous publications appearing monthly in prestigious journals, showcasing significant advancements in this field. The primary goal of this review is to present the most viable strategies for constructing the amide bond. It is crucial to differentiate between amide bond formation and amide synthesis; hence, the focus is on describing specific methods for forming new C(O)−N bonds. In particular, this review concentrates on the methods developed within the last six years. There is a particular emphasis on new approaches that consider the thought process when selecting the starting materials and functional groups. This approach ensures coverage of all the most common chemical transformations that yield new amide bonds.

更新日期：2023-11-07

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