Visible Light Induced Copper-Catalyzed Enantioselective Deaminative Arylation of Amino Acid Derivatives Assisted by Phenol,Angewandte Chemie International Edition

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Visible Light Induced Copper-Catalyzed Enantioselective Deaminative Arylation of Amino Acid Derivatives Assisted by Phenol
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2023-11-07 , DOI: 10.1002/anie.202312102
Yue Jia ₁ , Zhihan Zhang ₁ , Guo-Ming Yu ₁ , Xuan Jiang ₁ , Liang-Qiu Lu _{1,

2,

3} , Wen-Jing Xiao _{1,

4,

5}

Affiliation

A visible light induced enantioselective deaminative arylation of amino acid derivatives by bifunctional copper catalysis is disclosed. A variety of α-aryl-N-phenylamides are prepared with good efficiency and high enantioselectivity. A possible reaction mechanism and an asymmetric induction mode have been proposed based on experimental and computational evidence.

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