博比特盐和 4-乙酰胺TEMPO 使用的最新进展,Chemical Communications

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博比特盐和 4-乙酰胺TEMPO 使用的最新进展
Chemical Communications ( IF 4.3 ) Pub Date : 2023-11-07 , DOI: 10.1039/d3cc04709a
Jean M Bray ₁ , Shannon M Stephens ₁ , Shayne M Weierbach ₁ , Karen Vargas ₁ , Kyle M Lambert ₁

Affiliation

使用 Bobbitt 盐（4-乙酰氨基-2,2,6,6-四甲基-1-氧代哌啶鎓四氟硼酸盐，1）及其稳定的有机氮氧化物对应物 ACT（4-乙酰氨基TEMPO，4-乙酰氨基）进行选择性氧化转化的合成方法的最新进展-2,2,6,6-四甲基哌啶-1-氧基, 2 ) 已导致在广泛学科中的应用不断增加。目前对这些无金属、环境友好且易于获取的有机氧化剂的应用和机理理解现在远远超出了1和2在选择性醇氧化中的开创性用途。醇、醚、胺、硫醇、C-H 键和其他官能团与1和2氧化的新合成方法以及该领域当前对这些过程的机理理解以及我们在该领域的贡献一起呈现。利用这些氧化剂独特性质的令人兴奋的新领域包括：药物发现和天然产物全合成的应用、木质素解聚和其他生物聚合物改性的新电催化方法的开发、体外和体内核苷修饰、超分子催化应用、新聚合物和材料的合成、有机氧化还原液流电池设计的增强、有机燃料电池的应用、能源存储的应用和进步、电化学传感器的开发以及可再生燃料的生产。

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Recent advancements in the use of Bobbitt's salt and 4-acetamidoTEMPO

Recent advances in synthetic methodologies for selective, oxidative transformations using Bobbitt's salt (4-acetamido-2,2,6,6-tetramethyl-1-oxopiperidinium tetrafluoroborate, 1) and its stable organic nitroxide counterpart ACT (4-acetamidoTEMPO, 4-acetamido-2,2,6,6-tetramethylpiperidine-1-oxyl, 2) have led to increased applications across a broad array of disciplines. Current applications and mechanistic understanding of these metal-free, environmentally benign, and easily accessible organic oxidants now span well-beyond the seminal use of 1 and 2 in selective alcohol oxidations. New synthetic methodologies for the oxidation of alcohols, ethers, amines, thiols, C–H bonds and other functional groups with 1 and 2 along with the field's current mechanistic understandings of these processes are presented alongside our contributions in this area. Exciting new areas harnessing the unique properties of these oxidants include: applications to drug discovery and natural product total synthesis, the development of new electrocatalytic methods for depolymerization of lignin and modification of other biopolymers, in vitro and in vivo nucleoside modifications, applications in supramolecular catalysis, the synthesis of new polymers and materials, enhancements in the design of organic redox flow batteries, uses in organic fuel cells, applications and advancements in energy storage, the development of electrochemical sensors, and the production of renewable fuels.

更新日期：2023-11-11

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