基于类玫瑰 CuS@普鲁士蓝/Pt 的均质比色策略用于检测多巴胺,Sensors

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基于类玫瑰 CuS@普鲁士蓝/Pt 的均质比色策略用于检测多巴胺
Sensors ( IF 3.4 ) Pub Date : 2023-11-07 , DOI: 10.3390/s23229029
Di Yang ₁ , Jiao Ran ₁ , Huafei Yi ₁ , Pujin Feng ₁ , Bingqian Liu ₁

Affiliation

开发有效的多巴胺检测方法至关重要。在本研究中，开发了一种基于硫化铜和普鲁士蓝/铂 (CuS@PB/Pt) 复合材料的多巴胺检测均相比色策略。首次合成了玫瑰状的CuS@PB/Pt复合材料，并发现当过氧化氢存在时，3,3',5,5'-四甲基联苯胺（TMB）由无色变为蓝色氧化态TMB。使用扫描电子显微镜（SEM）、能谱仪（EDS）和X射线光电子能谱仪（XPS）对CuS@PB/Pt复合材料进行了表征。此外，多巴胺与复合材料的结合抑制了 CuS@PB/Pt 复合材料的催化活性。TMB 的颜色变化可以通过紫外光谱和便携式智能手机检测设备进行评估。开发的比色传感器可用于定量分析 1 至 60 µM 之间的多巴胺，检测限为 0.28 µM。此外，该传感器在人血清样品中表现出良好的长期稳定性和良好的性能。与其他报道的方法相比，该策略可以快速执行（16 分钟），并且具有智能手机视觉检测的优势。便携式智能手机检测设备便携且用户友好，为血清提供便捷的比色分析。这种比色策略与其他试纸相结合，对于开发体外诊断方法也具有相当大的潜力。

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A Homogeneous Colorimetric Strategy Based on Rose-Like CuS@Prussian Blue/Pt for Detection of Dopamine

The development of effective methods for dopamine detection is critical. In this study, a homogeneous colorimetric strategy for the detection of dopamine based on a copper sulfide and Prussian blue/platinum (CuS@PB/Pt) composite was developed. A rose-like CuS@PB/Pt composite was synthesized for the first time, and it was discovered that when hydrogen peroxide was present, the 3,3′,5,5′-tetramethylbenzidine (TMB) changed from colorless into blue-oxidized TMB. The CuS@PB/Pt composite was characterized with a scanning electron microscope (SEM), an energy dispersive spectrometer (EDS), and an X-ray photoelectron spectrometer (XPS). Moreover, the catalytic activity of the CuS@PB/Pt composite was inhibited by the binding of dopamine to the composite. The color change of TMB can be evaluated by the UV spectrum and a portable smartphone detection device. The developed colorimetric sensor can be used to quantitatively analyze dopamine between 1 and 60 µM with a detection limit of 0.28 μM. Furthermore, the sensor showed good long-term stability and good performance in human serum samples. Compared with other reported methods, this strategy can be performed rapidly (16 min) and has the advantage of smartphone visual detection. The portable smartphone detection device is portable and user-friendly, providing convenient colorimetric analysis for serum. This colorimetric strategy also has considerable potential for the development of in vitro diagnosis methods in combination with other test strips.

更新日期：2023-11-07

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