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An underwater stable and durable gelatin composite hydrogel coating for biomedical applications
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2023-11-07 , DOI: 10.1039/d3tb01817b Luxing Wei 1 , Yuan Li 2 , Xiaoyong Qiu 3 , Xiaolai Zhang 3 , Xiaoyu Song 1 , Yunpeng Zhao 4 , Qing Yu 5 , Jinlong Shao 5 , Shaohua Ge 5 , Jun Huang 1
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2023-11-07 , DOI: 10.1039/d3tb01817b Luxing Wei 1 , Yuan Li 2 , Xiaoyong Qiu 3 , Xiaolai Zhang 3 , Xiaoyu Song 1 , Yunpeng Zhao 4 , Qing Yu 5 , Jinlong Shao 5 , Shaohua Ge 5 , Jun Huang 1
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Developing underwater stable and durable hydrogel coatings with drag-reducing, drug release, and antibacterial properties is essential for lots of biomedical applications. However, most hydrogel coatings cannot meet the requirement of underwater stability and versatility, which severely limits their widespread use. In this work, an underwater stable, durable and substrate-independent gelatin composite hydrogel (GMP) coating is developed through covalent crosslinks, where a silane coupling agent with an unsaturated double bond is grafted onto a substrate of co-deposited polydopamine and polyethylenimine. GMP coating can be easily coated onto various medical device surfaces, such as artificial joints, catheters, tracheal tubes and titanium alloys, showing excellent structural stability and mechanical tunability under extreme conditions of ultrasonic treatment for 1 h (400 W of ultrasonic power) or underwater shearing for 14 days (400 rpm). Besides, friction experiment reveals that GMP coating exhibits good lubrication properties (coefficient of friction < 0.003). The drug-loading and bacterial inhibition ring tests show that the GMP coating has a tunable drug release ability with the final releasing ratios of 70–95% by changing the content of poly (ethylene glycol) diacrylate. This work offers a scalable approach of fabricating bio-functional and stable hydrogel coatings, which can be potentially used in biomedical applications.
中文翻译：
用于生物医学应用的水下稳定耐用的明胶复合水凝胶涂层
开发具有减阻、药物释放和抗菌特性的水下稳定且耐用的水凝胶涂层对于许多生物医学应用至关重要。然而，大多数水凝胶涂层无法满足水下稳定性和多功能性的要求，这严重限制了其广泛使用。在这项工作中，通过共价交联开发了一种水下稳定、耐用且不依赖于基材的明胶复合水凝胶（GMP）涂层，其中将具有不饱和双键的硅烷偶联剂接枝到共沉积的聚多巴胺和聚乙烯亚胺的基材上。 GMP涂层可以方便地涂覆在各种医疗器械表面，如人工关节、导管、气管插管和钛合金等，在超声处理1小时（400 W超声功率）或水下的极端条件下表现出优异的结构稳定性和机械可调性剪切 14 天 (400 rpm)。此外，摩擦实验表明GMP涂层具有良好的润滑性能（摩擦系数<0.003）。载药量和抑菌环测试表明，通过改变聚乙二醇二丙烯酸酯的含量，GMP涂层具有可调节的药物释放能力，最终释放率为70%~95%。这项工作提供了一种制造生物功能且稳定的水凝胶涂层的可扩展方法，可潜在用于生物医学应用。
更新日期：2023-11-07
中文翻译：
用于生物医学应用的水下稳定耐用的明胶复合水凝胶涂层
开发具有减阻、药物释放和抗菌特性的水下稳定且耐用的水凝胶涂层对于许多生物医学应用至关重要。然而，大多数水凝胶涂层无法满足水下稳定性和多功能性的要求，这严重限制了其广泛使用。在这项工作中，通过共价交联开发了一种水下稳定、耐用且不依赖于基材的明胶复合水凝胶（GMP）涂层，其中将具有不饱和双键的硅烷偶联剂接枝到共沉积的聚多巴胺和聚乙烯亚胺的基材上。 GMP涂层可以方便地涂覆在各种医疗器械表面，如人工关节、导管、气管插管和钛合金等，在超声处理1小时（400 W超声功率）或水下的极端条件下表现出优异的结构稳定性和机械可调性剪切 14 天 (400 rpm)。此外，摩擦实验表明GMP涂层具有良好的润滑性能（摩擦系数<0.003）。载药量和抑菌环测试表明，通过改变聚乙二醇二丙烯酸酯的含量，GMP涂层具有可调节的药物释放能力，最终释放率为70%~95%。这项工作提供了一种制造生物功能且稳定的水凝胶涂层的可扩展方法，可潜在用于生物医学应用。
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