Excessive inflammation and defective angiogenesis can affect burn wound healing. Recently, naturally derived substances with anti-inflammatory and proangiogenic properties have attracted public attention. The design and fabrication of naturally derived substance-based bioactive hydrogels as wound dressings are of interest and important for regulating the complex microenvironment of the wound bed. Herein, we developed a hydrogel by self-assembling a natural herb (glycyrrhizic acid, GA) dynamic Schiff base crosslinking of hyaluronic acid derivatives and integrating deferoxamine (DFO). The naturally derived herbal GA endowed the bioactive hydrogel with a native anti-inflammatory capability. The introduction of dynamic bond crosslinking improved the hydrogel stability. In addition, dynamic crosslinking is conducive for integrating the naturally-derived DFO, delivering it to the wound site, and promoting angiogenesis. Rheological tests, injectability, degradation behavior, and drug release performance demonstrated the enhanced stability of the hydrogel and sustained release of DFO. Cytotoxicity, cell proliferation, and cell migration tests suggested that the hydrogel was biocompatible. Further, the hydrogel exerted anti-inflammatory and angiogenic effects and accelerated burn wound healing in rats. Therefore, the proposed hydrogel has the potential to be a natural, herb-based, bioactive dressing for burn wound management.

过度炎症和有缺陷的血管生成会影响烧伤创面的愈合。最近，具有抗炎和促血管生成特性的天然物质引起了公众的关注。作为伤口敷料的基于天然物质的生物活性水凝胶的设计和制造对于调节伤口床的复杂微环境而言是有趣且重要的。在此，我们通过自组装天然草药（甘草酸，GA）动态席夫碱交联透明质酸衍生物并整合去铁胺（DFO）开发了一种水凝胶。天然提取的草药 GA 赋予生物活性水凝胶天然的抗炎能力。动态键交联的引入提高了水凝胶的稳定性。此外，动态交联有利于整合天然来源的DFO，将其输送至伤口部位，促进血管生成。流变学测试、可注射性、降解行为和药物释放性能证明了水凝胶稳定性的增强和 DFO 的持续释放。细胞毒性、细胞增殖和细胞迁移测试表明该水凝胶具有生物相容性。此外，水凝胶还具有抗炎和血管生成作用，并加速大鼠烧伤伤口的愈合。因此，所提出的水凝胶有潜力成为一种天然的、基于草药的生物活性敷料，用于烧伤创面管理。