Mfap4：增强肝再生和慢性肝病治疗的有希望的靶点,npj Regenerative Medicine

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Mfap4：增强肝再生和慢性肝病治疗的有希望的靶点
npj Regenerative Medicine ( IF 6.4 ) Pub Date : 2023-11-07 , DOI: 10.1038/s41536-023-00337-9
Viktoriia Iakovleva _{1,

2,

3} , Anna Wuestefeld ₁ , Agnes Bee Leng Ong ₁ , Rong Gao ₁ , Neslihan Arife Kaya ₄ , May Yin Lee ₄ , Weiwei Zhai _{5,

6} , Wai Leong Tam _{3,

4} , Yock Young Dan _{2,

7} , Torsten Wuestefeld _{1,

8,

9}

Affiliation

Laboratory of In Vivo Genetics and Gene Therapy, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), 60 Biopolis Street, Singapore, 138672, Republic of Singapore.
Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Republic of Singapore.
Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Republic of Singapore.
Laboratory of Translational Cancer Biology, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), 60 Biopolis Street, Singapore, 138672, Republic of Singapore.
Key Laboratory of Zoological Systematics and Evolution, Institute of Zoology, Chinese Academy of Sciences, 100101, Beijing, China.
Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming, 650223, China.
Division of Gastroenterology and Hepatology, National University Health System, Singapore, 119074, Republic of Singapore.
School of Biological Science, Nanyang University of Singapore, Singapore, 637551, Republic of Singapore.
National Cancer Centre, Singapore, 169610, Republic of Singapore.

肝脏具有非凡的再生能力。然而，在慢性肝脏损伤的情况下，这种能力会耗尽，导致纤维化组织积聚并导致终末期肝病。通过针对再生中断来增强内源性再生能力是一种创新的治疗方法。我们建立了体内功能遗传筛选来识别此类再生中断。我们确定了最热门的微原纤维相关蛋白 4 (Mfap4)。肝细胞中 Mfap4 的敲低可增强细胞增殖，加速肝脏再生，并通过减少肝纤维化来减轻慢性肝病。靶向 Mfap4 可调节多种肝再生相关途径，包括 mTOR。我们的研究为基于 siRNA 的疗法增强肝细胞的肝脏再生开辟了道路。

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更新日期：2023-11-07

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