<br>溶液中小分子自组装均聚物球晶,Journal of the American Chemical Society

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溶液中小分子自组装均聚物球晶
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2023-11-03 , DOI: 10.1021/jacs.3c08356
Qiantao Song ₁ , Yi Li _{2,

3} , Zhicheng Jin ₂ , Hai Liu ₁ , Matthew N Creyer ₂ , Wonjun Yim ₄ , Yanping Huang ₅ , Xiaobing Hu ₆ , Tengyu He ₄ , Yajuan Li ₇ , Shana O Kelley ₃ , Lingyan Shi ₇ , Jiajing Zhou ₂ , Jesse V Jokerst _{2,

4,

8}

Affiliation

College of Biomass Science and Engineering, Key Laboratory of Leather Chemistry and Engineering of Ministry of Education, National Engineering Laboratory for Clean Technology of Leather Manufacture, Sichuan University, Chengdu 610065, China.
Department of Nano Engineering, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States.
Department of Biomedical Engineering, McCormick School of Engineering, Northwestern University, Evanston, Illinois 60208, United States.
Materials Science and Engineering Program, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States.
Center of Engineering Experimental Teaching, School of Chemical Engineering, Sichuan University, Chengdu 610065, China.
The NUANCE Center, Department of Materials Science and Engineering, Northwestern University, Evanston, Illinois 60208, United States.
Shu Chien─Gene Lay Department of Bioengineering, University of California San Diego, 9500 Gilman Dr, La Jolla, California 92093, United States.
Department of Radiology, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States.

聚合物球晶通常通过熔融结晶形成：溶液中的球晶生长很少见，需要复杂的聚合物和稀溶液。在这里，我们报告了在室温下通过简单分子苯-1,4-二硫醇（BDT）温和且独特地形成发光球晶。具体来说，BDT通过二硫键聚合成低聚物（PBDT），并在水性缓冲液中组装成均匀的超分子纳米颗粒；然后将这些纳米颗粒溶解回良溶剂（即二甲基甲酰胺）中的 PBDT 中，并在 10 分钟内进行链伸长形成球晶（rPBDT）。通过改变 PBDT 浓度和反应时间来调节球晶几何形状。由于 PBDT 的逐步聚合和重组，这些球晶不仅表现出坚固的结构，而且还表现出广泛的团簇触发发射。球晶的生物相容性和有效的细胞摄取进一步强调了它们作为可追踪药物载体的价值。该系统为设计多功能超结构提供了一条新途径，对于将小分子分层组装成复杂的生物系统具有价值。

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更新日期：2023-11-03

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