The solubility of hydrogen sulfide (H₂S) hydrate, which determines the minimum concentration required for hydrate stability, is critical for the production and transportation of natural gas and the safety of H₂S emissions. Herein, Raman spectroscopy was used to measure the solubility of H₂S hydrate in water at a temperature of 273.15–301.15 K and pressures ranging from the hydrate–liquid–vapor (H–Lw–V) three-phase equilibrium pressure for each temperature to 100 MPa. The results showed that the solubility of H₂S hydrate in water increases with temperature under H–Lw–V three-phase equilibrium conditions. Meanwhile, under hydrate–liquid two-phase equilibrium conditions, the solubility increases significantly with temperature at constant pressure but decreases slightly with pressure at constant temperature. The three-phase solubility can be expressed as $m_{{\mathrm{H}}_2\mathrm{S}}\left(\mathrm{m}\mathrm{o}\mathrm{l}\bullet \mathrm{k}{\mathrm{g}}^{-1}\right)=\mathrm{e}\mathrm{x}\mathrm{p}\left(-6176.6286/T+20.8318\right)$, where the temperature is in K, and the two-phase solubility also depends on the pressure in MPa: $m_{{\mathrm{H}}_2\mathrm{S}}\left(\mathrm{mol}\bullet {\mathrm{kg}}^{-1}\right)=\text{exp}\left[-21.1-0.0182P-\left(\mathit{6281}\mathit{.}\mathit{47}\mathit{-}\mathit{4}\mathit{.}\mathit{23}\mathit{P}\right)/T\right]$. In addition, a thermodynamic model based on the van der Waals-Platteeuw theory was developed to predict the solubility of H₂S hydrate in water and the relative deviations of the solubility of H₂S hydrate (AADP) demonstrating the model’s capability to accurately predict the H₂S hydrate solubility in water.