The search for new scaffolds is one of the important goals in the discovery of new pesticides, and the oxazoles as an important five-membered heterocyclic compound are widely used in the discovery of new pesticides. Oxazoles ring are often used as the scaffolding structure or bridging chain to connect different reactive groups. In recent years, oxazoles have made rapid progress in the discovery of new pesticides, especially in the discovery of fungicides, insecticides, and acaricides. A systematic review of the recent research progress of oxazoles in the discovery of new pesticides is of interest. Therefore, we comprehensively reviewed the application of oxazole compounds in the discovery of new pesticides from 2003 to 2023; summarized the fungicidal, antibacterial, insecticidal, acaricidal, and herbicidal activities of oxazoles; and discussed the structure–activity relationship, physiochemical and mechanism of action, with the aim of providing inspiration and ideas for the discovery of oxazoles as novel agrochemicals.

中文翻译：

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恶唑衍生物在农用化学品发现中的研究进展

寻找新的支架是新型农药发现的重要目标之一，恶唑类化合物作为重要的五元杂环化合物被广泛应用于新型农药的发现中。恶唑环通常用作支架结构或桥链来连接不同的反应基团。近年来，恶唑类化合物在新农药的发现方面取得了快速进展，特别是在杀菌剂、杀虫剂、杀螨剂的发现方面。对恶唑类化合物在新型农药发现方面的最新研究进展进行系统综述是很有意义的。因此，我们全面回顾了2003年至2023年恶唑类化合物在新农药发现中的应用情况；总结了恶唑类的杀菌、抗菌、杀虫、杀螨和除草活性；并对其构效关系、理化及作用机制进行了讨论，旨在为恶唑类新型农药的发现提供启发和思路。