Magnesium (Mg) metal has been proved to have the ability to inhibit tumor growth because the degradation products could inhibit tumor, and anodic oxidation treatment plus heat treatment could improve this properties because of its controllable degradation. Rare earth elements (REE) have also demonstrated the ability to inhibit tumor growth. Among various magnesium alloys, WE43 magnesium alloy (marked as WE43) shows promising potential in curing bone tumors due to its ability to release REE such as Yttrium (Y), Gadolinium (Gd), and Neodymium (Nd). In this study, WE43 metal was modified by anodic oxidation plus heat treatment and marked as AO. The antitumor properties of AO material were studied. The results showed that WE43 had the similar anti-tumor properties as that of pure Mg metal, and AO material had significant improved antitumor property than WE43 and Mg metals. AO treatment could enrich REE on the surface of WE43, which made it release higher levels of REE (Y, Nd, and Gd) than WE43 metal without treatment. The high level of REE could improve the anti-tumor properties of the WE43 alloy. This results indicated that WE43 alloy subjected to anodic oxidation plus heat treatment has the potential to be utilized as an effective material for anti-bone tumor applications.

镁（Mg）金属已被证明具有抑制肿瘤生长的能力，因为其降解产物可以抑制肿瘤，而阳极氧化处理加热处理可以因其可控降解而改善这种性能。稀土元素（REE）也被证明具有抑制肿瘤生长的能力。在各种镁合金中，WE43镁合金（标记为WE43）由于能够释放钇（Y）、钆（Gd）和钕（Nd）等稀土元素，在治疗骨肿瘤方面显示出良好的潜力。本研究采用阳极氧化加热处理的方法对WE43金属进行改性，并标记为AO。研究了AO材料的抗肿瘤特性。结果表明，WE43具有与纯镁金属相似的抗肿瘤性能，而AO材料的抗肿瘤性能较WE43和镁金属显着提高。 AO处理可以使WE43表面富集稀土元素，使其比未经处理的WE43金属释放出更高水平的稀土元素（Y、Nd和Gd）。高含量的REE可以提高WE43合金的抗肿瘤性能。这一结果表明，经过阳极氧化加热处理的WE43合金有潜力作为抗骨肿瘤应用的有效材料。