The purpose of this study was to investigate the impact of carrier hydrophilicity on solid self nano-emulsifying drug delivery system (SNEDDS) and self nano-emulsifying granule system (SEGS). The mesoporous calcium silicate (Ca-silicate) and hydroxypropyl-β-cyclodextrin (HP-β-CD) were utilised as hydrophobic carrier and hydrophilic carrier, respectively. The liquid SNEDDS formulation, composed of Tween80/Kollipohr EL/corn oil (35/50/15%) with 31% (w/w) dexibuprofen, was spray-dried and fluid-bed granulated together with Avicel using Ca-silicate or HP- β-CD as a solid carrier, producing four different solid SNEDDS and SEGS formulations. Unlike the Ca-silicate-based systems, spherical shape and aggregated particles were shown in HP-β-CD-based solid SNEDDS and SEGS, respectively. Molecular interaction was detected between Ca-silicate and the drug; though, none was shown between HP-β-CD and the drug. Each system prepared with either carrier gave no significant differences in micromeritic properties, crystallinity, droplet morphology, size, dissolution and oral bioavailability in rats. However, the HP-β-CD-based system more significantly improved the drug solubility than did the Ca-silicate-based system. Therefore, both carriers hardly affected the properties of both solid SNEDDS and SEGS; though, there were differences in the aspect of appearance, molecular interaction and solubility.

本研究的目的是探讨载体亲水性对固体自纳米乳化给药系统（SNEDDS）和自纳米乳化颗粒系统（SEGS）的影响。介孔硅酸钙（Ca-silicate）和羟丙基-β-环糊精（HP-β-CD）分别用作疏水性载体和亲水性载体。液体 SNEDDS 制剂由 Tween80/Kollipohr EL/玉米油 (35/50/15%) 和 31% (w/w) 右布洛芬组成，使用硅酸钙或 HP 与 Avicel 一起进行喷雾干燥和流化床造粒- β-CD作为固体载体，产生四种不同的固体SNEDDS和SEGS制剂。与硅酸钙基体系不同，HP-β-CD 基固体 SNEDDS 和 SEGS 中分别显示出球形和聚集颗粒。检测到硅酸钙与药物之间存在分子相互作用；然而，HP-β-CD 和药物之间没有显示任何结果。用任一载体制备的每个系统在微粒特性、结晶度、液滴形态、大小、溶出度和大鼠口服生物利用度方面没有显着差异。然而，基于 HP-β-CD 的系统比基于硅酸钙的系统更显着地提高了药物溶解度。因此，两种载体对固体SNEDDS和SEGS的性能几乎没有影响；但在外观、分子相互作用和溶解度方面存在差异。