Biomedical Applications of Cell Membrane-Based Biomimetic Nano-Delivery System,Advanced Therapeutics

当前位置： X-MOL 学术 › Adv. Therap. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Biomedical Applications of Cell Membrane-Based Biomimetic Nano-Delivery System
Advanced Therapeutics ( IF 3.7 ) Pub Date : 2023-11-04 , DOI: 10.1002/adtp.202300304
Dexin Zhang ₁ , Guodong Wang ₂ , Ningyi Ma ₁ , Ziyang Yuan ₁ , Yuqin Dong ₁ , Xin Huang ₁ , Haishi Qiao ₁ , Ke Ren _{2,

3}

Affiliation

Surface modification of nanoparticles (NPs) is crucial for their effective utilization in diverse medical conditions, as it addresses challenges such as rapid passive clearance by the immune system, damage to the reticuloendothelial system, lack of specific cell targeting, and inadequate biocompatibility. The natural cell membrane (CM)-coating technology has recently garnered considerable attention as an optimal strategy for enhancing artificial nanoformulations. This biomimetic technique directly confers inner NPs with multiple functions, such as immune evasion, precise targeting, and excellent biocompatibility, all of which are mediated by source cell-inherent surface membrane proteins. Additionally, engineering techniques originally designed to enhance existing theranostic modalities employed in clinical settings are applied to natural CM carriers, thereby improving the physical properties of nanomaterials to drive further advancements. In this comprehensive review, diverse CM sources, such as red blood cells, platelets, white blood cells, cancer cells, bacteria, and other unconventional types, the core NPs employed in these cell membrane-coated nanoparticles (CM-NPs), preparation methods, and the latest advancements of CM-NPs across diverse biomedical fields, are reviewed. Engineering strategies for enhancing natural CMs have also been emphasized. Furthermore, the review comprehensively addresses the major challenges and their corresponding solutions in the clinical translation of this evolving field.

中文翻译：

基于细胞膜的仿生纳米递送系统的生物医学应用

纳米粒子 (NP) 的表面修饰对于其在各种医疗条件下的有效利用至关重要，因为它解决了免疫系统快速被动清除、网状内皮系统损伤、缺乏特定细胞靶向以及生物相容性不足等挑战。天然细胞膜（CM）涂层技术作为增强人工纳米制剂的最佳策略最近引起了相当大的关注。这种仿生技术直接赋予内部纳米粒子多种功能，如免疫逃避、精确靶向和优异的生物相容性，所有这些功能都是由源细胞固有的表面膜蛋白介导的。此外，最初设计用于增强临床环境中现有治疗诊断方式的工程技术应用于天然 CM 载体，从而改善纳米材料的物理特性，推动进一步进步。在这篇综合综述中，不同的CM来源，如红细胞、血小板、白细胞、癌细胞、细菌和其他非常规类型，这些细胞膜包覆纳米粒子（CM-NPs）中使用的核心纳米粒子，制备方法以及 CM-NP 在不同生物医学领域的最新进展进行了综述。增强天然 CM 的工程策略也得到了强调。此外，该综述全面解决了这一不断发展的领域的临床转化中的主要挑战及其相应的解决方案。

更新日期：2023-11-04

点击分享查看原文

点击收藏

阅读更多本刊新发论文