Microporous and Mesoporous Materials ( IF 4.8 ) Pub Date : 2023-11-03 , DOI: 10.1016/j.micromeso.2023.112885
Shuai Wang , Yu Fei Wang , Wen Na Jiao , Jing Jin , Yong Heng Xing , Feng Ying Bai , Li Xian Sun
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The synthesis of MOF with imide-functionalized aromatic conjugated carboxylic acid ligands has been a hot topic of field. A novel biomimetic peroxidase material (Cu-BDCPPI) was designed, synthesized and characterized by combining imide-functionalized aromatic conjugated carboxylic acid ligands N, N′-bis (3,5-dicarboxyphenyl) homophthalic diimide (H4BDCPPI) and catalytically active copper ions. The potential catalytic effect of Cu-H4BDCPPI on peroxidase-like activity was found firstly. It can catalyze the typical colorimetric substrate 3,3′,5,5′-tetramethylbenzyl (TMB) from colorless to blue ox-TMB in the presence of H2O2, and its enzymatic catalytic activity is similar to that of natural horseradish peroxidase (HRP). So, based on the catalytic performance of Cu-BDCPPI, a colorimetric method and test strips can be established for the detection of H2O2 and ascorbic acid (AA). This work provides a feasible strategy for synthesizing MOF materials with peroxidase like properties, expanding the application of MOF materials in the field of biological analysis.
中文翻译:
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酰亚胺功能化 Cu-MOF:仿生过氧化物酶活性以及过氧化氢和抗坏血酸的检测
酰亚胺功能化芳香族共轭羧酸配体合成MOF一直是该领域的研究热点。通过将酰亚胺功能化的芳香族共轭羧酸配体N,N'-双(3,5-二羧基苯基)邻苯二甲酰亚胺(H 4 BDCPPI)与催化活性铜相结合,设计、合成并表征了一种新型仿生过氧化物酶材料( Cu - BDCPPI )离子。首次发现Cu-H 4 BDCPPI对类过氧化物酶活性的潜在催化作用。在H 2 O 2存在下可催化典型比色底物3,3',5,5'-四甲基苄基(TMB)从无色变为蓝色ox-TMB,其酶催化活性与天然辣根过氧化物酶相似(辣根过氧化物酶)。因此,基于Cu-BDCPPI的催化性能,可以建立检测H 2 O 2和抗坏血酸(AA)的比色方法和试纸条。该工作为合成具有类过氧化物酶特性的MOF材料提供了可行的策略,拓展了MOF材料在生物分析领域的应用。