Axially chiral heterobiaryl featuring indole framework are promising structure in pharmaceutically active molecule, many natural product, and asymmetric catalysis field. Thus, a variety of protocols have been realized for the construction these challenging scaffolds with C–C, C–N, and N–N chiral axes. So far, a series of reviews on the synthesis of axially chiral compounds have been reported. However, atroposelective construction of indole subunit was rarely disclosed. Herein, we summarized the recent advance in atroposelective synthesis of axially chiral heterobiaryl featuring indole skeleton dividing these strategies into four categories. This review mainly discussed the related mechanism, scope, and application.

具有吲哚骨架的轴向手性杂联芳基是药物活性分子、许多天然产物和不对称催化领域中很有前途的结构。因此，已经实现了多种协议来构建这些具有C -C、C -N 和N -N 手性轴的具有挑战性的支架。迄今为止，已经报道了一系列关于轴手性化合物合成的综述。然而，吲哚亚基的结构选择性构建却很少被公开。在此，我们总结了以吲哚骨架为特征的轴向手性杂联芳基的逆向选择性合成的最新进展，将这些策略分为四类。本文主要讨论了相关机制、范围和应用。