<br>相互作用模型：TRIM21 如何与细胞内免疫中的蛋白质协调,Small Methods

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相互作用模型：TRIM21 如何与细胞内免疫中的蛋白质协调
Small Methods ( IF 10.7 ) Pub Date : 2023-11-03 , DOI: 10.1002/smtd.202301142
Yisha Huang ₁ , Xuejuan Gao ₁ , Qing-Yu He ₁ , Wanting Liu ₁

Affiliation

含有三联基序的蛋白 21 (TRIM21) 被鉴定为胞质 E3 泛素连接酶和 FcR（片段可结晶受体），主要通过其 PRY/SPRY 结构域与蛋白质相互作用，并促进其蛋白酶体降解以调节细胞内免疫。但TRIM21如何参与细胞内免疫仍缺乏系统的了解。在此，我们对 TRIM21 相关文献进行了探讨，并提出了一个关于 TRIM21 如何在细胞质中协调蛋白质的相互作用模型。在这个新模型中，TRIM21通常通过两种方式与细胞内免疫中的各种蛋白质相互作用：一方面，TRIM21仅充当E3，泛素化大量含有特定干扰素调节因子、核转录因子kappaB、病毒传感器等的蛋白质，并涉及炎症反应。另一方面，TRIM21 既充当 E3 又充当特异性 FcR，可检测抗体复合物并促进抗体破坏靶蛋白。本文分别将TRIM21的相互作用如何促进细胞内免疫分别描述为Fc非依赖性信号传导和Fc依赖性信号传导，以期系统地了解这一重要蛋白，并为进一步研究相关疾病的发病机制及其未来应用提供启示。已详细阐述。

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A Interacting Model: How TRIM21 Orchestrates with Proteins in Intracellular Immunity

Tripartite motif-containing protein 21 (TRIM21), identified as both a cytosolic E3 ubiquitin ligase and FcR (Fragment crystallizable receptor), primarily interacts with proteins via its PRY/SPRY domains and promotes their proteasomal degradation to regulate intracellular immunity. But how TRIM21 involves in intracellular immunity still lacks systematical understanding. Herein, it is probed into the TRIM21-related literature and raises an interacting model about how TRIM21 orchestrates proteins in cytosol. In this novel model, TRIM21 generally interacts with miscellaneous protein in intracellular immunity in two ways: For one, TRIM21 solely plays as an E3, ubiquitylating a glut of proteins that contain specific interferon-regulatory factor, nuclear transcription factor kappaB, virus sensors and others, and involving inflammatory responses. For another, TRIM21 serves as both E3 and specific FcR that detects antibody-complexes and facilitates antibody destroying target proteins. Correspondingly delineated as Fc-independent signaling and Fc-dependent signaling in this review, how TRIM21's interactions contribute to intracellular immunity, expecting to provide a systematical understanding of this important protein and invest enlightenment for further research on the pathogenesis of related diseases and its prospective application is elaborated.

更新日期：2023-11-03

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