A Interacting Model: How TRIM21 Orchestrates with Proteins in Intracellular Immunity,Small Methods

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A Interacting Model: How TRIM21 Orchestrates with Proteins in Intracellular Immunity
Small Methods ( IF 10.7 ) Pub Date : 2023-11-03 , DOI: 10.1002/smtd.202301142
Yisha Huang ₁ , Xuejuan Gao ₁ , Qing-Yu He ₁ , Wanting Liu ₁

Affiliation

Tripartite motif-containing protein 21 (TRIM21), identified as both a cytosolic E3 ubiquitin ligase and FcR (Fragment crystallizable receptor), primarily interacts with proteins via its PRY/SPRY domains and promotes their proteasomal degradation to regulate intracellular immunity. But how TRIM21 involves in intracellular immunity still lacks systematical understanding. Herein, it is probed into the TRIM21-related literature and raises an interacting model about how TRIM21 orchestrates proteins in cytosol. In this novel model, TRIM21 generally interacts with miscellaneous protein in intracellular immunity in two ways: For one, TRIM21 solely plays as an E3, ubiquitylating a glut of proteins that contain specific interferon-regulatory factor, nuclear transcription factor kappaB, virus sensors and others, and involving inflammatory responses. For another, TRIM21 serves as both E3 and specific FcR that detects antibody-complexes and facilitates antibody destroying target proteins. Correspondingly delineated as Fc-independent signaling and Fc-dependent signaling in this review, how TRIM21's interactions contribute to intracellular immunity, expecting to provide a systematical understanding of this important protein and invest enlightenment for further research on the pathogenesis of related diseases and its prospective application is elaborated.

中文翻译：

相互作用模型：TRIM21 如何与细胞内免疫中的蛋白质协调

含有三联基序的蛋白 21 (TRIM21) 被鉴定为胞质 E3 泛素连接酶和 FcR（片段可结晶受体），主要通过其 PRY/SPRY 结构域与蛋白质相互作用，并促进其蛋白酶体降解以调节细胞内免疫。但TRIM21如何参与细胞内免疫仍缺乏系统的了解。在此，我们对 TRIM21 相关文献进行了探讨，并提出了一个关于 TRIM21 如何在细胞质中协调蛋白质的相互作用模型。在这个新模型中，TRIM21通常通过两种方式与细胞内免疫中的各种蛋白质相互作用：一方面，TRIM21仅充当E3，泛素化大量含有特定干扰素调节因子、核转录因子kappaB、病毒传感器等的蛋白质，并涉及炎症反应。另一方面，TRIM21 既充当 E3 又充当特异性 FcR，可检测抗体复合物并促进抗体破坏靶蛋白。本文分别将TRIM21的相互作用如何促进细胞内免疫分别描述为Fc非依赖性信号传导和Fc依赖性信号传导，以期系统地了解这一重要蛋白，并为进一步研究相关疾病的发病机制及其未来应用提供启示。已详细阐述。

更新日期：2023-11-03

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