Epilepsy is one of the most common neurological diseases, while over one third of adults with epilepsy still have inadequate seizure control. Although mutations in salt-inducible kinases (SIKs) have been identified in epileptic encephalopathy, it is not known whether blocking SIKs can prevent pentylenetetrazole (PTZ)-induced seizures.

中文翻译：

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用 YKL-06-061 阻断盐诱导激酶可预防 PTZ 诱导的小鼠癫痫发作

癫痫是最常见的神经系统疾病之一，而超过三分之一的成人癫痫患者仍然无法充分控制癫痫发作。尽管盐诱导激酶 (SIK) 突变已在癫痫性脑病中被发现，但尚不清楚阻断 SIK 是否可以预防戊四唑 (PTZ) 诱发的癫痫发作。