Chiral Sensing of Tryptophan Enantiomers Based on the Enzyme Mimics of β-Cyclodextrin-Modified Sulfur Quantum Dots,ACS Sensors

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Chiral Sensing of Tryptophan Enantiomers Based on the Enzyme Mimics of β-Cyclodextrin-Modified Sulfur Quantum Dots
ACS Sensors ( IF 8.2 ) Pub Date : 2023-11-02 , DOI: 10.1021/acssensors.3c01616
Weijia Jiang _{1,

2} , Ran He ₁ , Han Lv ₁ , Xinheng He _{3,

4} , Li Wang ₁ , Yanli Wei ₁

Affiliation

Chiral recognition of amino acid plays a significant role in pharmaceutical, medical, and food science. This study describes a chiral sensing system of β-cyclodextrin (β-CD)-coated sulfur quantum dots (CD-SQDs) for the selective fluorescence recognition of tryptophan (Trp) enantiomers. CD-SQDs were prepared by a facile assembly fission method and could selectively recognize L-Trp by the different binding ability between L/D-Trp and β-CD. The inclusion of L-Trp and the stereoselective catalysis of CD-SQDs enzyme mimics cause the increased fluorescence intensity of CD-SQDs, which has a linear response ranging from 10 to 500 nM and the detection limit as 2.3 nM. CD-SQDs also show great selectivity for L-Trp from the commercial compound amino acid injection. The study could provide an effective method for the chiral recognition of amino acid enantiomers based on the catalytic activity of nanoenzymes.

中文翻译：

基于β-环糊精修饰硫量子点的酶模拟物的色氨酸对映体手性传感

氨基酸的手性识别在制药、医学和食品科学中发挥着重要作用。本研究描述了一种 β-环糊精 (β-CD) 涂层硫量子点 (CD-SQD) 的手性传感系统，用于选择性荧光识别色氨酸 (Trp) 对映体。 CD-SQDs通过简单的组装裂变方法制备，并且可以通过L / D -Trp与β-CD之间不同的结合能力选择性地识别L -Trp。 L -Trp 的包含和 CD-SQDs 酶模拟物的立体选择性催化导致 CD-SQDs 的荧光强度增加，其线性响应范围为 10 至 500 nM，检测限为 2.3 nM。 CD-SQD 对商业复合氨基酸注射液中的L -Trp 也表现出良好的选择性。该研究可为基于纳米酶催化活性的氨基酸对映体手性识别提供有效方法。

更新日期：2023-11-02

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