富血小板纤维蛋白在牙槽骨再生中的作用及机制,Biomedicine & Pharmacotherapy

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富血小板纤维蛋白在牙槽骨再生中的作用及机制
Biomedicine & Pharmacotherapy ( IF 6.9 ) Pub Date : 2023-11-02 , DOI: 10.1016/j.biopha.2023.115795
Ming Liu ₁ , Yu Liu ₁ , Feng Luo ₁

Affiliation

富血小板纤维蛋白（PRF）作为一种自体血液制剂，近年来受到越来越多的关注，并已成功应用于口腔领域牙槽骨再生的各种临床治疗中。本文重点分析和总结PRF在牙槽骨再生中的作用和机制。我们首先对PRF进行简单介绍，然后从成骨机制、骨诱导机制、骨传导机制三个方面总结PRF促进牙槽骨再生的机制，涉及Smad、ERK1/2、PI3K/等多个信号通路。 Akt 和 Wnt/β-连环蛋白。我们还探讨了PRF作为支架、填充物以及与骨移植材料结合的各种作用，详细介绍了PRF如何促进牙槽骨再生，并提供了丰富的实验证据。最后，我们总结了目前PRF在各个口腔领域的应用。 PRF在牙槽骨再生中的作用越来越重要，其作用和机制正在得到越来越多的研究和认识。本文将为相关领域的研究提供重要的参考价值。探索PRF在牙槽骨再生中的作用和机制可能会导致新的治疗靶点的发现以及更有效和高效的治疗策略的开发。

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The role and mechanism of platelet-rich fibrin in alveolar bone regeneration

Platelet-rich fibrin (PRF), as an autologous blood preparation, has been receiving increasing attention in recent years and has been successfully applied in various clinical treatments for alveolar bone regeneration in the oral field. This review focuses on analyzing and summarizing the role and mechanism of PRF in alveolar bone regeneration. We first provide a brief introduction to PRF, then summarize the mechanisms by which PRF promotes alveolar bone regeneration from three aspects: osteogenesis mechanism, bone induction mechanism, and bone conduction mechanism, involving multiple signaling pathways such as Smad, ERK1/2, PI3K/Akt, and Wnt/β-catenin. We also explore the various roles of PRF as a scaffold, filler, and in combination with bone graft materials, detailing how PRF promotes alveolar bone regeneration and provides a wealth of experimental evidence. Finally, we summarize the current applications of PRF in various oral fields. The role of PRF in alveolar bone regeneration is becoming increasingly important, and its role and mechanism are receiving more and more research and understanding. This article will provide a reference of significant value for research in related fields. The exploration of the role and mechanism of PRF in alveolar bone regeneration may lead to the discovery of new therapeutic targets and the development of more effective and efficient treatment strategies.

更新日期：2023-11-02

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