A photoinduced copper-catalyzed alkoxyl triggered C−C bond cleavage/aminocarbonylation cascade is presented. Through adjusting the structure of alkoxyl radical precursors, functionalized lactones and keto-amides were synthesized with good yields and excellent functional group tolerance under redox-neutral conditions. Notably, this protocol enables the integration of lactone fragments with many amine drugs and drug fragments.

中文翻译：

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光诱导铜催化烷氧基自由基触发扩环/氨基羰基化级联

提出了光诱导铜催化烷氧基触发的 C−C 键断裂/氨基羰基化级联。通过调整烷氧基自由基前体的结构，在氧化还原中性条件下合成了具有良好收率和优异官能团耐受性的官能化内酯和酮酰胺。值得注意的是，该方案能够将内酯片段与许多胺类药物和药物片段整合。