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Bifidobacterium longum subsp. infantis B6MNI Alleviates Collagen-Induced Arthritis in Rats via Regulating 5-HIAA and Pim-1/JAK/STAT3 Inflammation Pathways
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2023-10-31 , DOI: 10.1021/acs.jafc.3c05371
Bowen Li 1, 2 , Mengfan Ding 1, 2 , Chi Chen 1, 2 , Jianxin Zhao 1, 2, 3 , Guoxun Shi 4 , Paul Ross 3, 5 , Catherine Stanton 3, 5, 6 , Wei Chen 1, 2, 7 , Bo Yang 1, 2, 3
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2023-10-31 , DOI: 10.1021/acs.jafc.3c05371
Bowen Li 1, 2 , Mengfan Ding 1, 2 , Chi Chen 1, 2 , Jianxin Zhao 1, 2, 3 , Guoxun Shi 4 , Paul Ross 3, 5 , Catherine Stanton 3, 5, 6 , Wei Chen 1, 2, 7 , Bo Yang 1, 2, 3
Affiliation
The immunomodulatory potential of certain bacterial strains suggests that they could be beneficial in the treatment of rheumatoid arthritis (RA). In this study, we investigated the effects of Bifidobacterium longum subsp. infantis B6MNI on the progression of collagen-induced arthritis (CIA) in rats as well as its influence on the gut microbiota and fecal metabolites. Forty-eight female Wistar rats were divided into six groups that included a B6MNI group with CIA and intragastrically administered B. longum subsp. infantis B6MNI (109 CFU/day/rat), a control group (CON), and a CIA group, both of which were intracardiacally administered the same volume of saline. Rats were sacrificed after short-term (ST, 4 weeks) or long-term (LT, 6 weeks) administration. The results indicate that B. longum subsp. infantis B6MNI can modulate the gut microbiota and fecal metabolites, including 5-hydroxyindole-3-acetic acid (5-HIAA), which in turn impacts the expression of Pim-1 and immune cell differentiation, then through the JAK-STAT3 pathway affects joint inflammation, regulates osteoclast differentiation factors, and delays the progression of RA. Our results also suggest that B. longum subsp. infantis B6MNI is most efficacious for the early or middle stages of RA.
中文翻译:
长双歧杆菌亚种 婴儿 B6MNI 通过调节 5-HIAA 和 Pim-1/JAK/STAT3 炎症途径减轻大鼠胶原诱导的关节炎
某些细菌菌株的免疫调节潜力表明它们可能有益于治疗类风湿性关节炎(RA)。在这项研究中,我们研究了长双歧杆菌亚种的影响。婴儿B6MNI 对大鼠胶原诱导性关节炎 (CIA) 的进展及其对肠道微生物群和粪便代谢物的影响。48 只雌性 Wistar 大鼠被分为六组,其中包括具有 CIA 的 B6MNI 组并胃内施用长双歧杆菌亚种。婴儿B6MNI(10 9 CFU/天/大鼠)、对照组(CON)和CIA组,均心内给予相同体积的盐水。短期(ST,4周)或长期(LT,6周)给药后处死大鼠。结果表明,B. longum subsp. 婴儿B6MNI 可以调节肠道微生物群和粪便代谢物,包括 5-羟基吲哚-3-乙酸 (5-HIAA),进而影响 Pim-1 的表达和免疫细胞分化,然后通过 JAK-STAT3 通路影响关节炎症,调节破骨细胞分化因子,延缓 RA 的进展。我们的结果还表明B. longum subsp。婴儿B6MNI 对于 RA 的早期或中期阶段最有效。
更新日期:2023-10-31
中文翻译:
长双歧杆菌亚种 婴儿 B6MNI 通过调节 5-HIAA 和 Pim-1/JAK/STAT3 炎症途径减轻大鼠胶原诱导的关节炎
某些细菌菌株的免疫调节潜力表明它们可能有益于治疗类风湿性关节炎(RA)。在这项研究中,我们研究了长双歧杆菌亚种的影响。婴儿B6MNI 对大鼠胶原诱导性关节炎 (CIA) 的进展及其对肠道微生物群和粪便代谢物的影响。48 只雌性 Wistar 大鼠被分为六组,其中包括具有 CIA 的 B6MNI 组并胃内施用长双歧杆菌亚种。婴儿B6MNI(10 9 CFU/天/大鼠)、对照组(CON)和CIA组,均心内给予相同体积的盐水。短期(ST,4周)或长期(LT,6周)给药后处死大鼠。结果表明,B. longum subsp. 婴儿B6MNI 可以调节肠道微生物群和粪便代谢物,包括 5-羟基吲哚-3-乙酸 (5-HIAA),进而影响 Pim-1 的表达和免疫细胞分化,然后通过 JAK-STAT3 通路影响关节炎症,调节破骨细胞分化因子,延缓 RA 的进展。我们的结果还表明B. longum subsp。婴儿B6MNI 对于 RA 的早期或中期阶段最有效。